| Blood still kills: six strategies to further reduce allogeneic blood transfusion-related mortality. | |
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MedLine Citation:
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PMID: 20303034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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After reviewing the relative frequency of the causes of allogeneic blood transfusion-related mortality in the United States today, we present 6 possible strategies for further reducing such transfusion-related mortality. These are (1) avoidance of unnecessary transfusions through the use of evidence-based transfusion guidelines, to reduce potentially fatal (infectious as well as noninfectious) transfusion complications; (2) reduction in the risk of transfusion-related acute lung injury in recipients of platelet transfusions through the use of single-donor platelets collected from male donors, or female donors without a history of pregnancy or who have been shown not to have white blood cell (WBC) antibodies; (3) prevention of hemolytic transfusion reactions through the augmentation of patient identification procedures by the addition of information technologies, as well as through the prevention of additional red blood cell alloantibody formation in patients who are likely to need multiple transfusions in the future; (4) avoidance of pooled blood products (such as pooled whole blood-derived platelets) to reduce the risk of transmission of emerging transfusion-transmitted infections (TTIs) and the residual risk from known TTIs (especially transfusion-associated sepsis [TAS]); (5) WBC reduction of cellular blood components administered in cardiac surgery to prevent the poorly understood increased mortality seen in cardiac surgery patients in association with the receipt of non-WBC-reduced (compared with WBC-reduced) transfusion; and (6) pathogen reduction of platelet and plasma components to prevent the transfusion transmission of most emerging, potentially fatal TTIs and the residual risk of known TTIs (especially TAS). |
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Authors:
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Eleftherios C Vamvakas; Morris A Blajchman |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Transfusion medicine reviews Volume: 24 ISSN: 1532-9496 ISO Abbreviation: Transfus Med Rev Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-06-01 Revised Date: 2010-08-02 |
Medline Journal Info:
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Nlm Unique ID: 8709027 Medline TA: Transfus Med Rev Country: United States |
Other Details:
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Languages: eng Pagination: 77-124 Citation Subset: IM |
Copyright Information:
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(c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Vamvakase@cshs.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Lung Injury
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etiology,
prevention & control Blood Transfusion / adverse effects, mortality*, trends Blood-Borne Pathogens / isolation & purification Disease Transmission, Infectious / prevention & control Donor Selection Evidence-Based Medicine / methods Female Guideline Adherence Hemolysis / physiology Humans Male Pregnancy Safety Management / methods* Transplantation, Homologous / adverse effects, mortality* |
| Comments/Corrections | |
Erratum In:
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Transfus Med Rev. 2010 Jul;24(3):257 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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