Document Detail

Blood purification in sepsis: a new paradigm.
MedLine Citation:
PMID:  20427984     Owner:  NLM     Status:  MEDLINE    
Sepsis is one of the main causes of death in critically ill patients. The pathophysiology of sepsis is complex and not completely understood. The proinflammatory and anti-inflammatory response leads to cell and organ dysfunction and, in many cases, death. Thus, the goal of the intervention is to restore the homeostasis of circulating mediators rather than to inhibit selectively the proinflammatory or anti-inflammatory mediators. Blood purification has been reported to remove a wide array of inflammatory mediators. The effects are broad-spectrum and auto-regulating. Blood purification has also been demonstrated to restore immune function through improving antigen-presenting capability, adjusting leukocyte recruitment, oxidative burst and phagocytosis, and improving leukocyte responsiveness. A great deal of work has to be done in order to find and optimize the best extracorporeal blood purification therapy for sepsis. New devices specifically target the pathophysiological mechanisms involved in these conditions. High-volume hemofiltration, hemoadsorption, coupled plasma filtration adsorption, and high cutoff membrane are now being tested in septic patients. Preliminary data indicate the feasibility of these modified techniques in sepsis. Their impact on patient prognosis, however, still needs proof by large randomized clinical trials. Finally, the emerging paradigm of sepsis-induced immune suppression provides additional rationale for the development of extracorporeal blood purification therapy for sepsis.
Zhiyong Peng; Kai Singbartl; Peter Simon; Thomas Rimmelé; Jeffery Bishop; Gilles Clermont; John A Kellum
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Publication Detail:
Type:  Journal Article     Date:  2010-04-20
Journal Detail:
Title:  Contributions to nephrology     Volume:  165     ISSN:  1662-2782     ISO Abbreviation:  Contrib Nephrol     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-29     Completed Date:  2010-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513582     Medline TA:  Contrib Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  322-8     Citation Subset:  IM    
Copyright Information:
2010 S. Karger AG, Basel.
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA.
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MeSH Terms
Blood Coagulation Factors / isolation & purification
Cause of Death
Chemokines / blood,  isolation & purification
Complement System Proteins / isolation & purification
Critical Illness
Cytokines / blood,  isolation & purification
Hemofiltration / methods*
Inflammation / blood
Inflammation Mediators / blood,  isolation & purification
Sepsis / etiology,  mortality,  physiopathology,  therapy*
Shock, Septic / etiology,  mortality,  physiopathology,  therapy
Reg. No./Substance:
0/Blood Coagulation Factors; 0/Chemokines; 0/Cytokines; 0/Inflammation Mediators; 9007-36-7/Complement System Proteins

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