Document Detail

Blood pressure in 12-year-old children is associated with fatty acid composition of human milk: the prevention and incidence of asthma and mite allergy birth cohort.
MedLine Citation:
PMID:  22926954     Owner:  NLM     Status:  MEDLINE    
Breastfed individuals have a lower blood pressure than formula-fed individuals. Supplementation with n-3 long-chain polyunsaturated fatty acids in adults is also associated with a lower blood pressure. We studied whether children receiving human milk with a relatively high content of n-3 long-chain polyunsaturated fatty acids have a lower blood pressure at age 12 years, and, if so, whether this association is explained by the n-3 long-chain polyunsaturated fatty acids content in erythrocyte membranes at age 12 years. Within a 12-year follow-up of a population-based birth cohort, we compared blood pressure of 205 never-breastfed children and 109 children who had fatty acid composition of their mothers' breast milk measured during lactation. In addition, 973 children had information on erythrocyte fatty acid composition and blood pressure at age 12 years. Children who received human milk with an n-3 long-chain polyunsaturated fatty acids content above the median (ie, 0.51 weight percentage) had a 4.79-mm Hg lower systolic (95% CI, -7.64 to -1.94) and a 2.47-mm Hg lower diastolic (95% CI, -4.45 to -0.49) blood pressure at age 12 years than never-breastfed children. N-3 long-chain polyunsaturated fatty acids levels in human milk below the median value and current n-3 long-chain polyunsaturated fatty acid status were not associated with blood pressure at age 12 years. Thus, a relatively high content of n-3 long-chain polyunsaturated fatty acids in human milk is associated with a lower blood pressure in children at age 12 years, a finding not explained by current n-3 long-chain polyunsaturated fatty acids status.
Lenie van Rossem; Alet H Wijga; Johan C de Jongste; Gerard H Koppelman; Marieke Oldenwening; Dirkje S Postma; Marieke Abrahamse-Berkeveld; Bert van de Heijning; Bert Brunekreef; Henriëtte A Smit
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-27
Journal Detail:
Title:  Hypertension     Volume:  60     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-13     Completed Date:  2012-12-14     Revised Date:  2013-04-19    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1055-60     Citation Subset:  IM    
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, PO Box 85500, 3508 GA, Utrecht, the Netherlands.
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MeSH Terms
Asthma / epidemiology*,  prevention & control
Blood Pressure / physiology*
Breast Feeding*
Fatty Acids, Omega-3 / analysis*
Hypersensitivity / epidemiology*,  prevention & control
Milk, Human / chemistry*
Reg. No./Substance:
0/Fatty Acids, Omega-3
Comment In:
Hypertension. 2013 Apr;61(4):e33   [PMID:  23399719 ]
Hypertension. 2013 Apr;61(4):e34-5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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