Document Detail


Blood pressure, vessel caliber, and retinal thickness in diabetes.
MedLine Citation:
PMID:  23160442     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: In this study, we examine the association of blood pressure (BP), retinal thickness (RT), and vessel caliber in patients with type 2 diabetes and high HbA1c (elevated long-term blood glucose) with or without mild or moderate nonproliferative diabetic retinopathy (NPDR).
METHODS: Forty-three patients with type 2 diabetes and high HbA1c measures (23 without NPDR and 20 with mild to moderate NPDR) and 22 age-matched nondiabetic controls participated. The BP, RT (Stratus OCT3), fundus photography, and HbA1c were measured. Correlations between BP, HbA1c, vessel caliber, and RT were evaluated.
RESULTS: Diastolic BP (DBP) is positively and significantly associated with RT in patients with NPDR (p < 0.02). Blood pressure was not associated with RT in patients without NPDR (p = 0.83). There is an association between higher HbA1c and higher DBP within the NPDR group (p < 0.02). Furthermore, HbA1c modifies the slope of the relationship between DBP and RT in NPDR patients. Greater venule diameters and loss of the correlation between decreased arteriole size and increased systolic blood pressure, seen in controls, were observed in patients with and without NPDR.
CONCLUSIONS: The results of this study show that HbA1c and BP together have an impact on RT measures of patients with DR. These measures should be considered when evaluating RT in patients with DR both clinically and in future optical coherence tomography studies on this population.
Authors:
Wendy W Harrison; Ann Chang; Maria G Cardenas; Marcus A Bearse; Marilyn E Schneck; Shirin Barez; Anthony J Adams
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Optometry and vision science : official publication of the American Academy of Optometry     Volume:  89     ISSN:  1538-9235     ISO Abbreviation:  Optom Vis Sci     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-28     Completed Date:  2013-05-21     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  8904931     Medline TA:  Optom Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1715-20     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Glucose / metabolism
Blood Pressure / physiology*
Diabetes Mellitus, Type 2 / blood,  diagnosis,  physiopathology*
Diabetic Retinopathy / diagnosis*,  etiology,  physiopathology
Female
Hemoglobin A, Glycosylated / metabolism
Humans
Male
Middle Aged
Retina / pathology*
Retinal Vessels / pathology*
Tomography, Optical Coherence
Grant Support
ID/Acronym/Agency:
EY002271/EY/NEI NIH HHS; EY007043/EY/NEI NIH HHS; R01 EY002271/EY/NEI NIH HHS; T32 EY007043/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The Effect of Daily Lens Replacement During Overnight Wear on Ocular Adverse Events.
Next Document:  Optometrists' Clinical Reasoning Made Explicit: A Qualitative Study.