| Blood Pressure and Vascular Dysfunction Underlie Elevated Cerebral Blood Flow in Systemic Lupus Erythematosus. | |
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MedLine Citation:
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PMID: 22247349 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: In previous studies cerebral blood flow (CBF) was found to be altered in patients with systemic lupus erythematosus (SLE) compared to controls. We investigated the relationships between CBF and clinical data from subjects with SLE with the aim of determining the pathologic factors underlying altered CBF in SLE. METHODS: A total of 42 SLE subjects and 19 age- and sex-matched healthy control subjects were studied. Dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) was used to measure CBF. Patients and controls underwent complete clinical and laboratory evaluations in close proximity with their MRI studies. RESULTS: A higher CBF was present in the SLE group and was independently associated in statistical models with higher systolic blood pressure (SBP; p < 0.01). The intensity of the relationships (slope of curve) between CBF and mean arterial blood pressure, diastolic blood pressure, or blood levels of tissue plasminogen activator in the SLE group was significantly blunted relative to the control group. CONCLUSION: These findings are consistent with an underlying cerebral hyperperfusion in SLE induced by elevated but nonhypertensive levels of SBP. The factors underlying this relationship may be functional and/or structural (atherosclerotic, thrombotic, thromboembolic, or vasculitic) cerebrovascular disease. |
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Authors:
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Charles Gasparovic; Clifford Qualls; Ernest R Greene; Wilmer L Sibbitt; Carlos A Roldan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-15 |
Journal Detail:
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Title: The Journal of rheumatology Volume: - ISSN: 0315-162X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Department of Psychology, Divisions of Cardiology and Rheumatology, Department of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, New Mexico; The Mind Research Network, Albuquerque, New Mexico; and Department of Biology and Chemistry, New Mexico Highlands University, Las Vegas, New Mexico, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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