| Blood Pressure Variability as Sign of Autonomic Imbalance in Patients with Idiopathic Dilated Cardiomyopathy. | |
| | |
MedLine Citation:
|
PMID: 22268614 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: The problem of identifying idiopathic dilated cardiomyopathy (IDC) patients who are at risk of sudden death is still unsolved. The presence of autonomic imbalance in patients with IDC might predict sudden death and tachyarrhythmic events. The aim of this study was to analyze the suitability of blood pressure variability (BPV) compared to heart rate variability (HRV) for noninvasive risk stratification in IDC patients. Methods: Continuous noninvasive blood pressure and high-resolution electrocardiogram were recorded from 91 IDC patients for 30 minutes . During a median follow-up period of 28 months (range: [17-38] months), 14 patients died due to sudden death or necessary resuscitation due to a life-threatening arrhythmia. HRV and BPV analyses were performed in time domain, frequency domain, and nonlinear dynamics. Using the Mann-Whitney U test and Cox regression, we estimated the accuracy of clinical and nonclinical parameters in discriminating high-risk from low-risk patients. Results: Dynamics of blood pressure regulation was significantly changed in high-risk patients, indicating an increased BPV. BPV indexes from nonlinear symbolic dynamics revealed significant univariate (sensitivity: 85.7%; specificity 77.9%; area under receiver-operator characteristics [ROC] curve: 87.8%) differences. In an optimum multivariate set consisting of two clinical indexes (left ventricular end-diastolic diameter, New York Heart Association) and one nonlinear index (symbolic dynamics), highly significant differences between low- and high-risk IDC groups were estimated (sensitivity of 92.9%, specificity of 86.5%, and area under ROC curve of 95.3%). Conclusion: Diastolic BPV indexes, especially those from symbolic dynamics, appear to be useful for risk stratification of sudden death in patients with IDC. (PACE 2011;1-9). |
| | |
Authors:
|
Andreas Voss; Matthias Goernig; Rico Schroeder; Sandra Truebner; Alexander Schirdewan; Hans R Figulla |
Related Documents
:
|
21770964 - Comparison of the pressure redistribution qualities of two air-filled wheelchair cushio... 22041554 - Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers are beneficia... 22022144 - Ambulatory blood pressure profile and left ventricular geometry in nigerian hypertensives. 8897404 - Clinical aspects of the control of plasma volume at microgravity and during return to o... 2629864 - Mitral flow velocity curves as a function of different loading conditions: evaluation b... 20044514 - Noninvasive assessment of murine pulmonary arterial pressure: validation and applicatio... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-23 |
Journal Detail:
|
Title: Pacing and clinical electrophysiology : PACE Volume: - ISSN: 1540-8159 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
©2012, The Authors. Journal compilation ©2012 Wiley Periodicals, Inc. |
Affiliation:
|
Department of Medical Engineering and Biotechnology, University of Applied Sciences Jena, Jena, Germany Clinic for Internal Medicine I, University Hospital of Jena, Jena, Germany Franz-Volhard-Clinic, Charité, Humboldt University of Berlin, Berlin, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reversible paraneoplastic encephalitis in three patients with ovarian neoplasms.
Next Document: Development of an ELISA method for testing VWF ristocetin co-factor activity with improved sensitivi...