Document Detail

Blood Pressure, Thyroid-Stimulating Hormone, and Thyroid Disease Prevalence in Primary Aldosteronism and Essential Hypertension.
MedLine Citation:
PMID:  21850059     Owner:  NLM     Status:  Publisher    
BackgroundA positive correlation between thyroid-stimulating hormone (TSH) and blood pressure (BP) has been identified in normotensives and in patients with essential hypertension (EH). This study was designed to evaluate, in primary aldosteronism (PA) and in EH, potential association of BP, TSH, and ultrasonographic changes of the thyroid.MethodsWe studied 188 patients: 92 with PA and 96 matched essential hypertensives. Clinical and ambulatory BP (ABP), and thyroid function were evaluated in all patients. In PA and in a subgroup of EH patients (n = 65) thyroid ultrasonography was performed.ResultsIn PA patients, diastolic office and diastolic ABP increased across TSH quartiles and multivariate analysis confirmed a positive significant correlation between TSH and diastolic BP, independently of aldosterone levels, body mass index (BMI), duration of hypertension, and age. In EH patients, we found a significant linear increase in systolic and diastolic ABP with increasing TSH. The prevalence of thyroid dysfunctions was similar in PA and EH (15% and 19%, respectively). In PA patients, we found a higher prevalence of ultrasonographic alterations than in EH (66% vs. 46%, P < 0.05). PA patients presenting morphological abnormalities had higher homeostasis model assessment-insulin resistance levels than patients with normal gland at ultrasonography (4.2 ± 1.8 vs. 3.1 ± 0.8 P < 0.05).ConclusionsWe found a positive correlation between TSH and BP both in PA and EH patients. Moreover, in PA patients we observed a high prevalence of thyroid morphological alterations.American Journal of Hypertension (2011). doi:10.1038/ajh.2011.144.
Federica Turchi; Vanessa Ronconi; Valentina di Tizio; Marco Boscaro; Gilberta Giacchetti
Related Documents :
9563729 - Safety of inducing sputum in patients with asthma of varying severity.
22009809 - The diagnostic accuracy of high resolution ultrasound imaging for detection of secondar...
2806509 - Energy expenditure and rib cage-abdominal motion in chronic obstructive pulmonary disease.
18037159 - Angiopoietin-2 as a contributing factor of exercise-induced bronchoconstriction in asth...
16700189 - Differential effect of cigarette smoking on hydrogen peroxide and thiobarbituric acid r...
9776479 - Individual variations in lymphocyte-responses to glucocorticoids in patients with bronc...
19833759 - Reevaluation of the role of duration of morning stiffness in the assessment of rheumato...
10450539 - Etofibrate decreases factor vii and fibrinogen levels in patients with polymetabolic sy...
22532159 - Pioglitazone therapy in progressive differentiated thyroid carcinoma.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-18
Journal Detail:
Title:  American journal of hypertension     Volume:  -     ISSN:  1941-7225     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Internal Medicine, Division of Endocrinology, Università Politecnica delle Marche, Ospedali Riuniti "Umberto I-G.M. Lancisi-G. Salesi", Ancona, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intraprocedural Cortisol Measurement Increases Adrenal Vein Sampling Success Rate in Primary Aldoste...
Next Document:  Are Retinal Microvascular Phenotypes Associated With the 1675G/A Polymorphism in the Angiotensin II ...