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Blood Pressure and Retinal Microvascular Characteristics During Pregnancy: Growing Up in Singapore Towards Healthy Outcomes (GUSTO) Study.
MedLine Citation:
PMID:  22615113     Owner:  NLM     Status:  Publisher    
Changes in maternal blood pressure during pregnancy are associated with poor maternal and neonatal outcomes. We investigated whether maternal blood pressure during midpregnancy has an impact on the retinal microcirculation among pregnant Asian women. A total of 665 pregnant women aged 18 to 46 years were recruited from the Growing Up in Singapore Towards Healthy Outcomes Study. Blood pressure and retinal vascular parameters were both measured at 26 weeks' gestation following a standardized protocol. Blood pressure was measured by a digital automatic blood pressure monitor (Omron HEM 705 LP). Quantitative retinal vascular parameters were assessed by a semiautomated computer-based program (Singapore I Vessel Assessment, version 3.0). In multiple linear regression models, every 10-mm Hg increase in mean arterial blood pressure was associated with a 1.9-μm (P<0.001) reduction in retinal arteriolar caliber, a 0.9° (P=0.05) reduction in retinal arteriolar branching angle, and a 0.07 (P<0.01) reduction in retinal arteriolar fractal dimension, respectively. Patients classified into a high-risk group in developing preeclampsia (mean arterial blood pressure ≥90 mm Hg) were twice as likely (odds ratio 2.1 [95% CI, 1.0-4.4]) to have generalized retinal arteriolar narrowing compared with those classified into a low-risk group (mean arterial blood pressure <90 mm Hg). Retinal venular caliber and vascular tortuosity were not associated with blood pressure measures. Elevated blood pressure is associated with a range of retinal arteriolar changes in pregnant women, providing evidence for an impact of blood pressure on the microcirculation during pregnancy.
Ling-Jun Li; Carol Yim-Lui Cheung; M Kamran Ikram; Peter Gluckman; Michael J Meaney; Yap-Seng Chong; Kenneth Kwek; Tien-Yin Wong; Seang-Mei Saw
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-21
Journal Detail:
Title:  Hypertension     Volume:  -     ISSN:  1524-4563     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Saw Swee Hock School of Public Health, National University of Singapore, Singapore; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Departments of Ophthalmology and Obstetrics and Gynecology, National University Hospital, Singapore; DUKE-NUS Graduate Medical School, Singapore; Department of Ophthalmology, Erasmus Medical Centre, Rotterdam, the Netherlands; Singapore Institute for Clinical Sciences A*STAR, Singapore; Departments of Psychiatry and Neurology, McGill University, Montreal, Quebec, Canada; Kandang Kerbau Women's and Children's Hospital, Singapore; Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia.
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