Document Detail

Blood pressure-independent factors determine the susceptibility to delayed neuronal death in the stroke-prone spontaneously hypertensive rats.
MedLine Citation:
PMID:  19731009     Owner:  NLM     Status:  MEDLINE    
The stroke-prone spontaneously hypertensive rat (SHRSP) is vulnerable to delayed neuronal death (DND) in the CA1 subfield of the hippocampus after the transient forebrain ischemia by the occlusion of the bilateral carotid arteries. The present study was designed to show that the genetic factors independent of high blood pressure contributed to the high incidence of DND in SHRSP. Male rats of the four strains, SHRSP/Izm, SHRSP/Ngsk, SHR/Izm and a congenic strain for the blood pressure quantitative trait locus on chromosome 1 [SHRSP.WKY-(D1Wox29-D1Arb21)/Izm]were used in the experiments. At 13 weeks of age, the bilateral carotid arteries of rats were occluded for 10 min under anesthesia with their body temperature kept at 37 degreeC. Seven days after the transient ischemia, the loss of the pyramidal cells in the CA1 was evaluated histologically. In some experiments, the blood flow was monitored with a laser Doppler flowmeter during the transient ischemia. The blood pressure in SHRSP/Izm was significantly greater than that in the other three strains. The incidence of DND, however, was not significantly different among SHRSP/Izm, SHRSP/Ngsk and the congenic strain (82, 74 and 65%, respectively), while SHR/Izm showed a significantly lower incidence (20 percent). Neither a significant correlation between the incidence of DND and the blood flow reduction during the occlusion, nor a significant inter-strain difference in the blood flow reduction was observed. The genetic factors independent of high blood pressure may contribute to the greater susceptibility to DND in SHRSP.
Yasuko Sakurai-Yamashita; Toru Nabika; Masami Niwa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cellular and molecular neurobiology     Volume:  30     ISSN:  1573-6830     ISO Abbreviation:  Cell. Mol. Neurobiol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-25     Completed Date:  2010-10-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200709     Medline TA:  Cell Mol Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  283-7     Citation Subset:  IM    
Department of Pharmacology 1, Nagasaki University GraduateSchool of Biomedical Sciences, Nagasaki 852-8523, Japan.
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MeSH Terms
Blood Pressure / physiology*
Cell Death* / genetics
Cerebrovascular Circulation / physiology
Genetic Predisposition to Disease*
Neurons / pathology*
Quantitative Trait Loci
Rats, Inbred SHR*
Regional Blood Flow
Stroke / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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