Document Detail


Blood pressure change in normotensive, gestational hypertensive, preeclamptic, and essential hypertensive pregnancies.
MedLine Citation:
PMID:  22526257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared patterns of blood pressure (BP) change among normotensive women, women who developed gestational hypertension or preeclampsia, and women who had essential hypertension to examine how distinct these conditions are and whether rates of BP change may help to identify women at risk for hypertensive disorders. We used antenatal clinic BP measurements (median, 14 per woman) of 13016 women from the Avon Longitudinal Study of Parents and Children who had a singleton or twin live birth surviving until ≥ 1 year. Linear spline models were used to describe changes in systolic and diastolic BPs in different periods of pregnancy (8-18, 18-30, 30-36, and ≥ 36 weeks' gestation). Women who had essential hypertension and those who developed gestational hypertension or preeclampsia had higher BP at 8 weeks' gestation (baseline) compared with normotensive women. The decrease in BP until 18 weeks was smaller in gestational hypertensive compared with normotensive pregnancies. BP rose more rapidly from 18 weeks onward in gestational hypertensive and preeclamptic pregnancies and from 30 weeks onward in essential hypertensive compared with normotensive pregnancies. Women who developed preeclampsia had a more rapid increase in BP from 30 weeks onward than those who developed gestational hypertension or had essential hypertension. Our findings indicate notable patterns of BP change that distinguish women with essential hypertension, gestational hypertension, and preeclampsia from each other and from normotensive women, even from early pregnancy. These distinct patterns may be useful for identifying women at risk of developing a hypertensive disorder later in pregnancy.
Authors:
Corrie Macdonald-Wallis; Debbie A Lawlor; Abigail Fraser; Margaret May; Scott M Nelson; Kate Tilling
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-23
Journal Detail:
Title:  Hypertension     Volume:  59     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-17     Completed Date:  2012-07-25     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1241-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Blood Pressure / physiology*
Female
Gestational Age
Humans
Hypertension / physiopathology*
Hypertension, Pregnancy-Induced / physiopathology*
Infant
Infant, Newborn
Linear Models
Longitudinal Studies
Pre-Eclampsia / physiopathology*
Pregnancy
Pregnancy Complications, Cardiovascular / physiopathology*
Time Factors
Young Adult
Grant Support
ID/Acronym/Agency:
087997//Wellcome Trust; 092731//Wellcome Trust; G0600705//Medical Research Council; G0701594//Medical Research Council; R01DK077659/DK/NIDDK NIH HHS; WT087997MA//Wellcome Trust
Comments/Corrections
Comment In:
Hypertension. 2012 Jun;59(6):1099-100   [PMID:  22526256 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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