| Blood pressure and cardiovascular disease: tracing the steps from Framingham. | |
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MedLine Citation:
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PMID: 20620424 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Around one-quarter of the world's adult population are defined as "hypertensive" however a much greater proportion are at risk of blood pressure-related disease because of the nature of the association between blood pressure and cardiovascular risk. The Framingham Study, together with other landmark observational studies, has been instrumental in elucidating this relationship. As early as the 1960s, Framingham showed that the association between blood pressure and cardiovascular risk was continuous and linear and was consistent across different age groups and for a range of major cardiovascular events. As the first major observational study to include substantial numbers of women, it was also able to debunk the myth that women "could tolerate blood pressure well". In more recent decades, Framingham has been central to the development of the notion of absolute risk and the importance of blood pressure alongside other risk factors. Much of our current understanding of the role blood pressure in cardiovascular disease can be attributed to decades of high quality research from Framingham. |
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Authors:
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Fiona Turnbull; Andre Pascal Kengne; Stephen MacMahon |
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Publication Detail:
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Type: Historical Article; Journal Article |
Journal Detail:
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Title: Progress in cardiovascular diseases Volume: 53 ISSN: 1873-1740 ISO Abbreviation: Prog Cardiovasc Dis Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-08-09 Revised Date: 2013-05-02 |
Medline Journal Info:
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Nlm Unique ID: 0376442 Medline TA: Prog Cardiovasc Dis Country: United States |
Other Details:
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Languages: eng Pagination: 39-44 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Cardiovascular Division, The George Institute for International Health, Camperdown, NSW 2050, Australia. fturnbull@george.org.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Blood Pressure* Cardiovascular Diseases / epidemiology, etiology*, history, physiopathology Evidence-Based Medicine Female History, 20th Century History, 21st Century Humans Hypertension / complications*, epidemiology, history, physiopathology Male Middle Aged National Institutes of Health (U.S.) Population Surveillance* Risk Assessment Risk Factors Sex Factors Time Factors United States / epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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