Document Detail

Blood Oxidative Stress Markers During a High Altitude Trek.
MedLine Citation:
PMID:  23006582     Owner:  NLM     Status:  Publisher    
Oxidative stress occurs as a result of altitude induced hypobaric hypoxia and physical exercise. The effect of exercise on oxidative stress under hypobaric hypoxia is not well understood. Purpose: To determine the effect of high altitude exercise on blood oxidative stress. Nine male participants completed a 2-day trek up and down Mt Rainer, in North America at a peak altitude of 4,393m. Day one consisted of steady pace climbing for 6.25 hours to a final elevation of 3000 meters. The 4,393 meter summit was reached on day two in approximately 5 hours. Climb-rest intervals varied but were consistent between participants, with approximately 14 hours of total time including rest periods. Blood samples were assayed for biomarkers of oxidative stress and antioxidant potential at the following time points: "Pre" (before the trek), "3Kup" (at ascent to 3,000 meters), "3Kdown" (at 3000 meters on the descent), and "Post" (post-trek at base elevation). Blood serum variables included ferric-reducing antioxidant potential (FRAP), trolox equivalent antioxidant capacity (TEAC), protein carbonyls (PC), and lipid hydroperoxides. Serum FRAP was elevated at 3Kup and 3Kdown compared to Pre and Post values (p=0.004, 8% and 11% increase from Pre). Serum TEAC values were increased at 3Kdown and Post trek (p=0.032, 10% and 18% increase from Pre). Serum PC were elevated at 3Kup and 3Kdown time points (p=0.034, 194% and 138% increase from Pre), while lipid hydroperoxides were elevated Post only (p=0.004, 257% increase from Pre). CONCLUSIONS: Findings indicate high altitude trekking is associated with increased blood oxidative stress.
Lindsey E Miller; Graham R McGinnis; Brian Kliszczewicz; Dustin Slivka; Walter Hailes; John Cuddy; Charles Dumke; Brent Ruby; John C Quindry
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-19
Journal Detail:
Title:  International journal of sport nutrition and exercise metabolism     Volume:  -     ISSN:  1543-2742     ISO Abbreviation:  Int J Sport Nutr Exerc Metab     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939812     Medline TA:  Int J Sport Nutr Exerc Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Cardioprotection Laboratory, Department of Kinesiology, Auburn University, Auburn, AL.
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