Document Detail

Blood glucose regulation during prolonged, submaximal, continuous exercise: a guide for clinicians.
MedLine Citation:
PMID:  20513337     Owner:  NLM     Status:  MEDLINE    
Management of many chronic diseases now includes regular exercise as part of a viable treatment plan. Exercise in the form of prolonged, submaximal, continuous exercise (SUBEX; i.e., approximately 30 min to 1 h, approximately 40-70% of maximal oxygen uptake) is often prescribed due to its relatively low risk, the willingness of patients to undertake, its efficacy, its affordability, and its ease of prescription. Specifically, patients who are insulin resistant or that have type 2 diabetes mellitus may benefit from regular exercise of this type. During this type of exercise, muscles dramatically increase glucose uptake as the liver increases both glycogenolysis and gluco-neogenesis. While a redundancy of mechanisms is at work to maintain blood glucose concentration ([glucose]) during this type of exercise, the major regulator of blood glucose is the insulin/glucagon response. At exercise onset, blood [glucose] transiently rises before beginning to decline after approximately 30 min, causing a subsequent decline in blood [insulin] and rise in blood glucagon. This leads to many downstream effects, including an increase in glucose output from the liver to maintain adequate glucose in the blood to fuel both the muscles and the brain. Finally, when analyzing blood [glucose], consideration should be given to nutritional status (postabsorptive versus postprandial) as well as both what the analyzer measures and the type of sample used (plasma versus whole blood). In view of both prescribing exercise to patients as well as designing studies that perturb glucose homeostasis, it is imperative that clinicians and researchers alike understand the controls of blood glucose homeostasis during SUBEX.
Matthew L Goodwin
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Publication Detail:
Type:  Journal Article     Date:  2010-05-01
Journal Detail:
Title:  Journal of diabetes science and technology     Volume:  4     ISSN:  1932-2968     ISO Abbreviation:  J Diabetes Sci Technol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-01     Completed Date:  2010-11-16     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101306166     Medline TA:  J Diabetes Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  694-705     Citation Subset:  IM    
Copyright Information:
(c) 2010 Diabetes Technology Society.
Weill Cornell Medical College, Cornell University, New York, New York 10021 , USA.
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MeSH Terms
Blood Glucose / physiology*
Exercise / physiology*
Exercise Therapy
Glucagon / metabolism
Insulin / metabolism
Reg. No./Substance:
0/Blood Glucose; 0/Insulin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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