| Blood gene expression reveal pathway differences between diet-sensitive and resistant obese subjects prior to caloric restriction. | |
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MedLine Citation:
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PMID: 20885385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Weight loss in response to caloric restriction displays significant interindividual heterogeneity. To develop early predictors of weight-loss success, we have compared whole-blood gene expression profiles of obese, diet-sensitive vs. obese, diet-resistant subjects prior to the initiation of clinically supervised caloric restriction. Pathway enrichment analysis of gene expression profiles by multiple applications converged on the "oxidative phosphorylation" (OXPHOS) pathway, and to a lesser extent the "proteasome" pathway, as statistically significantly upregulated in obese, diet-sensitive subjects compared to the diet-resistant subjects. The finding of increased OXPHOS is consistent with earlier observations of increased proton leak, increased expression of OXPHOS genes, and increased oxidative muscle fibers in skeletal muscle of obese, diet-sensitive subjects. The current study further highlights the utility of blood as a sentinel tissue reflecting systemic states and provides a potential modality to predict future weight-loss success, relevant to the design of individualized bariatric treatment programs. |
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Authors:
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Sujoy Ghosh; Robert Dent; Mary E Harper; Joan Stuart; Ruth McPherson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-09-30 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 19 ISSN: 1930-739X ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: 2011-04-29 Revised Date: 2012-08-13 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 457-63 Citation Subset: IM |
Affiliation:
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Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, North Carolina, USA. sghosh@nccu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Caloric Restriction* Cohort Studies Female Gene Expression Profiling Humans Male Middle Aged Obesity / diet therapy*, genetics*, metabolism Oxidative Phosphorylation* Protons Treatment Failure Weight Loss / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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5R25HL059868-10/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Protons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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