Document Detail

Blood gases and retinopathy of prematurity: the ELGAN Study.
MedLine Citation:
PMID:  20689332     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study tested the hypothesis that preterm infants who had a blood gas derangement on at least 2 of the first 3 postnatal days are at increased risk for more severe retinopathy of prematurity (ROP).
METHOD: 1,042 infants born before 28 weeks' gestational age (GA) were included. An infant was considered to be exposed if his/her blood gas measure was in the highest or lowest quartile for GA on at least 2 of the first 3 postnatal days.
RESULTS: Multivariable models adjusting for confounders indicate that exposure to a PCO(2) in the highest quartile predicts ROP (stage 3, 4 or 5: OR = 1.6, 95% CI = 1.1-2.3); zone 1: 2.0, 1.1-3.6; prethreshold/threshold: 1.9, 1.2-3.0; plus disease: 1.8, 1.1-2.9). Estimates are similar for a low pH for zone 1 (2.1, 1.2-3.8), prethreshold/threshold (1.8, 1.1-2.8), but did not quite achieve statistical significance for ROP stage 3, 4, or 5 (1.4, 0.9-2.0) and plus disease (1.5, 0.9-2.4). A PaO(2) in the highest quartile for GA on at least 2 of the first 3 postnatal days was associated with a doubling of the risk of ROP in zone 1 (2.5, 1.4-4.4) and of prethreshold/threshold disease (2.1, 1.4-3.3), a 70% risk increase for plus disease (1.7, 1.04-2.8), while a 40% risk increase for ROP stage 3 or higher did not achieve statistical significance (1.4, 0.96-2.0).
CONCLUSION: Infants exposed to high PCO(2), low pH and high PaO(2) appear to be at increased risk of more severe ROP.
Alisse K Hauspurg; Elizabeth N Allred; Deborah K Vanderveen; Minghua Chen; Francis J Bednarek; Cynthia Cole; Richard A Ehrenkranz; Alan Leviton; Olaf Dammann
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-07-30
Journal Detail:
Title:  Neonatology     Volume:  99     ISSN:  1661-7819     ISO Abbreviation:  Neonatology     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-04     Completed Date:  2011-06-14     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  104-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
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MeSH Terms
Carbon Dioxide / blood*
Hydrogen-Ion Concentration
Infant, Newborn
Infant, Premature / blood*
Logistic Models
Multivariate Analysis
Oxygen / blood*
Retinopathy of Prematurity / blood*
Grant Support
1R21EY019253-01/EY/NEI NIH HHS; 5U01NS040069-05/NS/NINDS NIH HHS; P30-HD-18655/HD/NICHD NIH HHS; R21 EY019253/EY/NEI NIH HHS; R21 EY019253-01/EY/NEI NIH HHS; R21 EY019253-02/EY/NEI NIH HHS
Reg. No./Substance:
142M471B3J/Carbon Dioxide; S88TT14065/Oxygen

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