| Blood flow in the foreign-body capsules surrounding surgically implanted subcutaneous devices. | |
| | |
MedLine Citation:
|
PMID: 19628222 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Surgically implanted devices initiate inflammatory mechanisms and wound healing events and result in the formation of a thick fibrotic capsule that surrounds the device. To investigate the foreign-body response to devices of clinically relevant size, we used microspheres to determine regional blood flow patterns in the foreign-body capsule (FBC) and surrounding subcutaneous tissue after device implantation. MATERIALS AND METHODS: In 10 canines, we implanted 40 subcutaneous devices (polysulfone n = 20, silicone-coated n = 10, titanium n = 10). Via thoracotomy, animals were instrumented with left atrial and aortic vascular access catheters for serial microsphere injections and reference blood sampling. Regional blood flow was repeatedly determined in the FBC, subcutaneous fascia surrounding the FBC, and subcutaneous fascia distal to the surgical site up to 19 wk after device implantation (n = 55 determinations). RESULTS: Compared with normal blood flow in subcutaneous fascia distal to the surgical site, blood flow increased in FBCs surrounding each device material (polysulfone P = 0.0035, silicone-coated P < 0.0001, titanium P < 0.0001). Additionally, blood flow increased in the subcutaneous fascia within half a centimeter of fibrous capsules encasing polysulfone (P = 0.0081) but not silicone (P = 0.3706) or titanium (P = 0.8160) devices. The time-course of measured blood flow changes within FBCs were similar for polysulfone and silicone but not for titanium. CONCLUSIONS: Surgically implanted subcutaneous devices of clinically relevant size elicit increases in blood flow in the FBC as well as surrounding fascia. Device material may influence regional blood flow patterns. |
| | |
Authors:
|
Carlo R Bartoli; John J Godleski |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: The Journal of surgical research Volume: 158 ISSN: 1095-8673 ISO Abbreviation: J. Surg. Res. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2009-12-16 Completed Date: 2010-01-07 Revised Date: 2011-07-19 |
Medline Journal Info:
|
Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: United States |
Other Details:
|
Languages: eng Pagination: 147-54 Citation Subset: IM |
Affiliation:
|
Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA. crbart02@louisville.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Dogs Female Foreign Bodies / physiopathology* Microspheres Prostheses and Implants* Regional Blood Flow Subcutaneous Tissue / blood supply* |
| Grant Support | |
ID/Acronym/Agency:
|
ES00002/ES/NIEHS NIH HHS; R01 ES012972-01/ES/NIEHS NIH HHS; R01 ES012972-02/ES/NIEHS NIH HHS; R01 ES012972-03/ES/NIEHS NIH HHS; R01 ES012972-04/ES/NIEHS NIH HHS; R01 ES012972-05/ES/NIEHS NIH HHS; R01 ES12972/ES/NIEHS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association of posttraumatic stress disorder with low-grade elevation of C-reactive protein: Evidenc...
Next Document: Mannitol attenuates kidney damage induced by xanthine oxidase-associated pancreas ischemia-reperfusi...