Document Detail


Blood flow restriction enhances post-resistance exercise angiogenic gene expression.
MedLine Citation:
PMID:  22677927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The objective of this study is to evaluate the effects of blood flow restriction (BFR) on muscle oxygenation during low-intensity resistance exercise as well as postexercise expression of molecules related to physiological angiogenesis.
METHODS: Using a randomized cross-over design, six apparently healthy young adults (22 ± 1 yr) performed 120 unilateral knee extensions at 40% of 1 repetition maximum with and without BFR (CNTRL). Near-infrared spectroscopy was used to measure oxygenation of the vastus lateralis during exercise. Serum and muscle expression of Post-Resistance vascular endothelial growth factor (VEGF) were determined preexercise, 4 h postexercise, and 24 h postexercise. Transcript (mRNA) expression of VEGF and other angiogenic genes was also determined.
RESULTS: BFR increased muscle hemoglobin (Hb) concentrations during exercise (14.4 ± 1.6 vs. 0.9 ± 1.6, P = 0.002), driven largely by an increase in deoxygenated Hb (11.0 ± 2.5 vs. 0.5 ± 1.1, P = 0.030). BFR also increased (P < 0.05) transcript expression of VEGF, VEGF-R2, hypoxia-inducible factor 1 alpha, inducible nitric oxide synthase (NOS), and neuronal NOS. The most dramatic change in response to BFR was an increase in VEGF mRNA at 4 h postexercise (4.1 ± 0.6 vs. 0.6 ± 0.2-fold change, P = 0.028). Compared with control, transcript expression of endothelial NOS, serum VEGF, or muscle protein expression of VEGF was not altered in response to BFR (P > 0.05).
CONCLUSION: Acute BFR increases postexercise expression of mRNA related to skeletal muscle angiogenesis, plausibly in response to changes in muscle Hb concentrations.
Authors:
Kelly A Larkin; R Gavin Macneil; Marvin Dirain; Bhanupresad Sandesara; Todd M Manini; Thomas W Buford
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  44     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-18     Completed Date:  2013-04-16     Revised Date:  2014-07-10    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2077-83     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Constriction, Pathologic / metabolism*
Cross-Over Studies
Female
Gene Expression*
Humans
Male
Neovascularization, Physiologic / genetics*
Oxygen Consumption / physiology
Physical Exertion / genetics*,  physiology
Quadriceps Muscle / blood supply*
RNA, Messenger / metabolism
Resistance Training*
Young Adult
Grant Support
ID/Acronym/Agency:
1KL2RR029888/RR/NCRR NIH HHS; 1P30AG028740/AG/NIA NIH HHS; 5UL1RR029890/RR/NCRR NIH HHS; KL2 RR029888/RR/NCRR NIH HHS; P30 AG028740/AG/NIA NIH HHS; UL1 RR029890/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Messenger
Comments/Corrections

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