| Blood flow restriction enhances post-resistance exercise angiogenic gene expression. | |
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MedLine Citation:
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PMID: 22677927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The objective of this study is to evaluate the effects of blood flow restriction (BFR) on muscle oxygenation during low-intensity resistance exercise as well as postexercise expression of molecules related to physiological angiogenesis. METHODS: Using a randomized cross-over design, six apparently healthy young adults (22 ± 1 yr) performed 120 unilateral knee extensions at 40% of 1 repetition maximum with and without BFR (CNTRL). Near-infrared spectroscopy was used to measure oxygenation of the vastus lateralis during exercise. Serum and muscle expression of Post-Resistance vascular endothelial growth factor (VEGF) were determined preexercise, 4 h postexercise, and 24 h postexercise. Transcript (mRNA) expression of VEGF and other angiogenic genes was also determined. RESULTS: BFR increased muscle hemoglobin (Hb) concentrations during exercise (14.4 ± 1.6 vs. 0.9 ± 1.6, P = 0.002), driven largely by an increase in deoxygenated Hb (11.0 ± 2.5 vs. 0.5 ± 1.1, P = 0.030). BFR also increased (P < 0.05) transcript expression of VEGF, VEGF-R2, hypoxia-inducible factor 1 alpha, inducible nitric oxide synthase (NOS), and neuronal NOS. The most dramatic change in response to BFR was an increase in VEGF mRNA at 4 h postexercise (4.1 ± 0.6 vs. 0.6 ± 0.2-fold change, P = 0.028). Compared with control, transcript expression of endothelial NOS, serum VEGF, or muscle protein expression of VEGF was not altered in response to BFR (P > 0.05). CONCLUSION: Acute BFR increases postexercise expression of mRNA related to skeletal muscle angiogenesis, plausibly in response to changes in muscle Hb concentrations. |
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Authors:
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Kelly A Larkin; R Gavin Macneil; Marvin Dirain; Bhanupresad Sandesara; Todd M Manini; Thomas W Buford |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 44 ISSN: 1530-0315 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-18 Completed Date: 2013-04-16 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 2077-83 Citation Subset: IM; S |
Affiliation:
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Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32607, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Constriction, Pathologic
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metabolism* Cross-Over Studies Female Gene Expression* Humans Male Neovascularization, Physiologic / genetics* Oxygen Consumption / physiology Physical Exertion / genetics*, physiology Quadriceps Muscle / blood supply* RNA, Messenger / metabolism Resistance Training* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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1KL2RR029888/RR/NCRR NIH HHS; 1P30AG028740/AG/NIA NIH HHS; 5UL1RR029890/RR/NCRR NIH HHS; KL2 RR029888/RR/NCRR NIH HHS; P30 AG028740/AG/NIA NIH HHS; UL1 RR029890/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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