Document Detail


Blood-flow characteristics in a terminal basilar tip aneurysm prior to its fatal rupture.
MedLine Citation:
PMID:  20150312     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: The development and validation of methods to stratify the risk of rupture of cerebral aneurysms is highly desired because current treatment risks can exceed the natural risk of rupture. Because unruptured aneurysms are typically treated before they rupture, it is very difficult to connect the proposed risk indices to the rupture of an individual aneurysm. The purpose of this case study was to analyze the hemodynamic environment of a saccular aneurysm of the terminal morphology subtype that was imaged just before its rupture and to test whether the hemodynamic characteristics would designate this particular aneurysm as at high risk.
MATERIALS AND METHODS: A patient-specific CFD model was constructed from 3DRA images acquired just hours before the aneurysm ruptured. A pulsatile flow calculation was performed, and hemodynamic characteristics previously connected to rupture were analyzed.
RESULTS: It was found that the aneurysm had a concentrated inflow stream, small impingement region, complex intra-aneurysmal flow structure, asymmetric flow split from the parent vessel to the aneurysm and daughter branches, and high levels of aneurysmal WSS near the impaction zone.
CONCLUSIONS: The hemodynamic characteristics observed in this aneurysm right before its rupture are consistent with previous studies correlating aneurysm rupture and hemodynamic patterns in saccular and terminal aneurysms. This study supports the notion that hemodynamic information may be used to help stratify the rupture risk of cerebral aneurysms.
Authors:
D M Sforza; C M Putman; E Scrivano; P Lylyk; J R Cebral
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-02-11
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  31     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-22     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1127-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aneurysm, Ruptured / epidemiology,  physiopathology*,  radiography*
Cerebral Angiography
Cerebrovascular Circulation
Fatal Outcome
Female
Humans
Intracranial Aneurysm / epidemiology,  physiopathology*,  radiography*
Middle Aged
Models, Cardiovascular
Risk Factors
Subarachnoid Hemorrhage / epidemiology,  physiopathology,  radiography
Tomography, X-Ray Computed*
Grant Support
ID/Acronym/Agency:
R01 NS 059063/NS/NINDS NIH HHS; R01 NS059063/NS/NINDS NIH HHS; R01 NS059063-03/NS/NINDS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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