Document Detail


Blomhotin: a novel peptide with smooth muscle contractile activity identified in the venom of Agkistrodon halys blomhoffii.
MedLine Citation:
PMID:  10519653     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel peptide has been isolated from the venom of Agkistrodon halys blomhoffii using a bioassay that monitors the stimulant effect on rat stomach fundus. The 11-amino acid peptide, named blomhotin, was purified to homogeneity by gel-filtration column chromatography and reverse-phase HPLC. The amino acid sequence of blomhotin was determined to be pGlu-Gly-Arg-Pro-Pro-Gly-Pro-Pro-Ile-Pro-Arg, which is similar to that of bradykinin-potentiating peptides which themselves cause no contraction of smooth muscle. The contraction induced by blomhotin showed homologous desensitization, implicating the involvement of a blomhotin-specific site in the response.
Authors:
R Yanoshita; A Kasuga; S Inoue; K Ikeda; Y Samejima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  37     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  1999 Dec 
Date Detail:
Created Date:  1999-10-28     Completed Date:  1999-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1761-70     Citation Subset:  IM    
Affiliation:
Institute of Medical Chemistry, Hoshi University, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Chromatography, Gel
Chromatography, High Pressure Liquid
Crotalid Venoms / chemistry*
Dose-Response Relationship, Drug
Gastric Fundus / drug effects
Male
Mass Spectrometry
Molecular Sequence Data
Muscle Contraction / drug effects*
Muscle, Smooth / drug effects*
Oligopeptides / isolation & purification,  pharmacology*
Rats
Rats, Wistar
Viperidae*
Chemical
Reg. No./Substance:
0/Crotalid Venoms; 0/Oligopeptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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