| Blomhotin: a novel peptide with smooth muscle contractile activity identified in the venom of Agkistrodon halys blomhoffii. | |
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MedLine Citation:
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PMID: 10519653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel peptide has been isolated from the venom of Agkistrodon halys blomhoffii using a bioassay that monitors the stimulant effect on rat stomach fundus. The 11-amino acid peptide, named blomhotin, was purified to homogeneity by gel-filtration column chromatography and reverse-phase HPLC. The amino acid sequence of blomhotin was determined to be pGlu-Gly-Arg-Pro-Pro-Gly-Pro-Pro-Ile-Pro-Arg, which is similar to that of bradykinin-potentiating peptides which themselves cause no contraction of smooth muscle. The contraction induced by blomhotin showed homologous desensitization, implicating the involvement of a blomhotin-specific site in the response. |
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Authors:
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R Yanoshita; A Kasuga; S Inoue; K Ikeda; Y Samejima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Toxicon : official journal of the International Society on Toxinology Volume: 37 ISSN: 0041-0101 ISO Abbreviation: Toxicon Publication Date: 1999 Dec |
Date Detail:
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Created Date: 1999-10-28 Completed Date: 1999-10-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1307333 Medline TA: Toxicon Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1761-70 Citation Subset: IM |
Affiliation:
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Institute of Medical Chemistry, Hoshi University, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Chromatography, Gel Chromatography, High Pressure Liquid Crotalid Venoms / chemistry* Dose-Response Relationship, Drug Gastric Fundus / drug effects Male Mass Spectrometry Molecular Sequence Data Muscle Contraction / drug effects* Muscle, Smooth / drug effects* Oligopeptides / isolation & purification, pharmacology* Rats Rats, Wistar Viperidae* |
| Chemical | |
Reg. No./Substance:
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0/Crotalid Venoms; 0/Oligopeptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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