| Blocking the renin-angiotensin-aldosterone system or lowering the blood pressure: does EUROPA help? | |
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MedLine Citation:
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PMID: 14689366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The EUropean trial on Reduction Of cardiac events with Perindopril in stable coronary Artery disease (EUROPA) demonstrated that the angiotensin- converting enzyme inhibitor, perindopril, compared with placebo, in patients with established coronary artery disease, reduced cardiovascular endpoints by 20% over a four-year follow-up period. Although the authors of this study claim that the risk reduction was best explained by blockade of the renin-angiotensin-aldosterone system, reference to recent meta-analyses of blood pressure (BP)-lowering trials provides compelling evidence that the benefits observed in the trial could be explained by the 5/2 mmHg BP difference between active and placebo treatments. |
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Authors:
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Judy A Mackay |
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Publication Detail:
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Type: Comment; Journal Article; Review |
Journal Detail:
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Title: Journal of the renin-angiotensin-aldosterone system : JRAAS Volume: 4 ISSN: 1470-3203 ISO Abbreviation: J Renin Angiotensin Aldosterone Syst Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-22 Completed Date: 2004-01-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100971636 Medline TA: J Renin Angiotensin Aldosterone Syst Country: England |
Other Details:
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Languages: eng Pagination: 205-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Hillingdon Hospital, Uxbridge, UB8 3NN, UK. judyasever@aol.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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therapeutic use* Antihypertensive Agents / therapeutic use* Blood Pressure / drug effects* Controlled Clinical Trials as Topic Coronary Disease / drug therapy Heart Diseases / prevention & control Humans Perindopril / therapeutic use* Renin-Angiotensin System / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 82834-16-0/Perindopril |
| Comments/Corrections | |
Comment On:
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J Renin Angiotensin Aldosterone Syst. 2000 Jun;1(2):117-8
[PMID:
11967800
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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