| Blocking lymphocyte localization to the gastrointestinal mucosa as a therapeutic strategy for inflammatory bowel diseases. | |
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MedLine Citation:
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PMID: 21530744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lymphocyte migration (homing) to specific tissues has an important role during protective and pathological immune responses, including inflammatory bowel diseases. Lymphocytes use integrin α4β7 and the chemokine receptor CCR9 to localize to the gastrointestinal mucosa; their respective ligands, mucosal addressin cell adhesion molecule-1 and CCL25, are displayed on endothelial cells in intestinal postcapillary venules. Although gastrointestinal-homing receptors are required for lymphocyte migration to the intestine in the noninflamed steady state, their role during inflammation is a matter of debate. Reagents designed to block interactions between these receptors and their ligands have had variable degrees of success in animal models of inflammatory bowel diseases and patients. We discuss the mechanisms involved in lymphocyte localization to the intestinal mucosa and how they can be applied to therapy for inflammatory bowel diseases. |
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Authors:
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Eduardo J Villablanca; Barbara Cassani; Ulrich H von Andrian; J Rodrigo Mora |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gastroenterology Volume: 140 ISSN: 1528-0012 ISO Abbreviation: Gastroenterology Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-02 Completed Date: 2011-07-12 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: United States |
Other Details:
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Languages: eng Pagination: 1776-84 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Chemokines / antagonists & inhibitors Gastric Mucosa / pathology* Humans Immunosuppressive Agents / therapeutic use Inflammatory Bowel Diseases / drug therapy*, pathology* Intestinal Mucosa / pathology* Lymphocytes / pathology* Membrane Glycoproteins / antagonists & inhibitors Receptors, Lymphocyte Homing / antagonists & inhibitors* |
| Grant Support | |
ID/Acronym/Agency:
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DP2 2009A054301/DP/NCCDPHP CDC HHS; DP2 OD006512-01/OD/NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Chemokines; 0/Immunosuppressive Agents; 0/Membrane Glycoproteins; 0/Receptors, Lymphocyte Homing; 0/adhesion receptor |
| Comments/Corrections | |
Erratum In:
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Gastroenterology. 2011 Aug;141(2):778 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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