Document Detail


Blocking lymphocyte localization to the gastrointestinal mucosa as a therapeutic strategy for inflammatory bowel diseases.
MedLine Citation:
PMID:  21530744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lymphocyte migration (homing) to specific tissues has an important role during protective and pathological immune responses, including inflammatory bowel diseases. Lymphocytes use integrin α4β7 and the chemokine receptor CCR9 to localize to the gastrointestinal mucosa; their respective ligands, mucosal addressin cell adhesion molecule-1 and CCL25, are displayed on endothelial cells in intestinal postcapillary venules. Although gastrointestinal-homing receptors are required for lymphocyte migration to the intestine in the noninflamed steady state, their role during inflammation is a matter of debate. Reagents designed to block interactions between these receptors and their ligands have had variable degrees of success in animal models of inflammatory bowel diseases and patients. We discuss the mechanisms involved in lymphocyte localization to the intestinal mucosa and how they can be applied to therapy for inflammatory bowel diseases.
Authors:
Eduardo J Villablanca; Barbara Cassani; Ulrich H von Andrian; J Rodrigo Mora
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  140     ISSN:  1528-0012     ISO Abbreviation:  Gastroenterology     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-07-12     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1776-84     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
Affiliation:
Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Chemokines / antagonists & inhibitors
Gastric Mucosa / pathology*
Humans
Immunosuppressive Agents / therapeutic use
Inflammatory Bowel Diseases / drug therapy*,  pathology*
Intestinal Mucosa / pathology*
Lymphocytes / pathology*
Membrane Glycoproteins / antagonists & inhibitors
Receptors, Lymphocyte Homing / antagonists & inhibitors*
Grant Support
ID/Acronym/Agency:
DP2 2009A054301/DP/NCCDPHP CDC HHS; DP2 OD006512-01/OD/NIH HHS; P30 AI060354/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Chemokines; 0/Immunosuppressive Agents; 0/Membrane Glycoproteins; 0/Receptors, Lymphocyte Homing; 0/adhesion receptor
Comments/Corrections
Erratum In:
Gastroenterology. 2011 Aug;141(2):778

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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