Document Detail

Blocking Vertical Transmission of Human T-Cell Lymphotropic Virus Type 1 and 2 through Breastfeeding Interruption.
MedLine Citation:
PMID:  22683674     Owner:  NLM     Status:  Publisher    
BACKGROUND-: Human T-cell Lymphotropic Virus type 1 and 2 (HTLV-1/2) causes serious diseases and is endemic in many parts of the world. It is transmitted from mother to child in 15 to 25% of the cases, primarily through breastfeeding. Proviral load and duration of breastfeeding are thought to play a role in transmission. This study aimed to detect HTLV seropositive mothers through testing of neonates, to evaluate maternal HTLV proviral load, and measure the rates of transmission blocking when interruption of breastfeeding was implemented. METHODS-: Neonates were screened for HTLV-1/2 IgG by Enzyme Immunoassay (EIA) utilizing the neonatal screening program of Minas Gerais State, Brazil. Breastfeeding interruption was recommended to those whose mothers were confirmed HTLV positive. Children were tested by polymerase chain reaction (PCR) at birthand with 12 months of age. RESULTS-: Of 55,293 neonates tested, 42 (0.076%) were positive for HTLV-1 or 2 IgG. All 42 were PCR negativeat birth and 1/37 (2.7%) became antibody positive after 12 months. His mother had delivered him vaginally and was informed of the positive HTLV-1 PCR after 7 days of breastfeeding. The mother's proviralload was 271 copies/10,000 cells, whereas the average is 109.2 copies/10,000 cells (95% CI: 70.56-147.83). DISCUSSION-: Maternal HTLV-1 proviral and the route of delivery may have played a role in the transmission observed. Avoidance of breastfeeding was an effective measure to reduce HTLV transmission. In endemic countries routine pre-natal or neonatal screening combined with formula feeding for mothers confirmed HTLV positive may be an important strategy to prevent future development of illnesses related to HTLV.
Maísa A Ribeiro; Marina L Martins; Carolina Teixeira; Roberto Ladeira; Maria de Fátima Oliveira; José Nélio Januário; Fernando A Proietti; Anna Bárbara F Carneiro-Proietti
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-7
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  -     ISSN:  1532-0987     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Fundação Hemominas; 2Fundação Hospitalar do Estado de Minas Gerais (FHEMIG); 3Núcleo de Ações e Pesquisa em Apoio Diagnóstico (NUPAD); 4Observatório de Saúde Urbana Universidade Federal de Minas Gerais (UFMG), Grupo de Pesquisas em Epidemiologia (GPE/CNPq), Departamento de Medicina Preventiva e Social; 5Faculdade de Saúde e Ecologia Humana (FASEH).
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