| Blocking the deadly effects of the NMDA receptor in stroke. | |
| | |
MedLine Citation:
|
PMID: 20141829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Excessive activation of NMDA glutamate receptors contributes to neuronal death after stroke. In this issue, Tu et al. (2010) demonstrate that ischemic injury promotes the association of death-associated protein kinase 1 with the NMDA receptor, thereby potentiating its activity, and show that disrupting this association reduces damage to the brain. |
| | |
Authors:
|
Henry G S Martin; Yu Tian Wang |
Related Documents
:
|
18946539 - Altered excitatory-inhibitory balance in the nmda-hypofunction model of schizophrenia. 8136409 - Synaptic integration of nmda and non-nmda receptors in large neuronal network models so... 8616639 - N-methyl-d-aspartate stimulates dopamine release through nitric oxide formation in the ... 1831299 - Rapid alteration of synaptic number and postsynaptic thickening length by nmda: an elec... 16908409 - Nmda receptor-nitric oxide transmission mediates neuronal iron homeostasis via the gtpa... 12724149 - Excitatory synaptic transmission in the lateral and central amygdala. 18384819 - Enhancement of long-term potentiation by brain-derived neurotrophic factor requires ade... 17278219 - Pretreatment with adenosine and adenosine a1 receptor agonist protects against intestin... 8188079 - Identification of insulin and insulin-like growth factor i (igf i) receptors in ovarian... |
Publication Detail:
|
Type: Comment; Journal Article |
Journal Detail:
|
Title: Cell Volume: 140 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2010-02-09 Completed Date: 2010-02-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
|
Languages: eng Pagination: 174-6 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Brain Research Centre, Vancouver Coastal Health Research Institute and University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Apoptosis Regulatory Proteins / antagonists & inhibitors, metabolism* Brain / metabolism, pathology Brain Ischemia / metabolism, pathology Calcium-Calmodulin-Dependent Protein Kinases / antagonists & inhibitors, metabolism* Peptides / metabolism Receptors, N-Methyl-D-Aspartate / metabolism* Stroke / drug therapy, metabolism*, pathology |
| Chemical | |
Reg. No./Substance:
|
0/Apoptosis Regulatory Proteins; 0/NR2B NMDA receptor; 0/Peptides; 0/Receptors, N-Methyl-D-Aspartate; EC 2.7.11.1/death-associated protein kinase; EC 2.7.11.17/Calcium-Calmodulin-Dependent Protein Kinases |
| Comments/Corrections | |
Comment On:
|
Cell. 2010 Jan 22;140(2):222-34
[PMID:
20141836
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Driving Innovation: Ready, Set, Go!
Next Document: Forever Young.