Document Detail


Blockage of glucocorticoid receptors during memory acquisition, retrieval and reconsolidation prevents the expression of morphine-induced conditioned place preferences in mice.
MedLine Citation:
PMID:  23389984     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Association between the reward caused by consuming drugs and the context in which they are consumed is essential in the formation of morphine-induced conditioned place preference (CPP). Glucocorticoid receptor (GRs) activation in different regions of the brain affects reward-based reinforcement and memory processing. A wide array of studies have demonstrated that blockage of GRs in some brain areas can have an effect on reward-related memory; however, to date there have been no systematic studies about the involvement of glucocorticoids (GCs) in morphine-related reward memory. Here, we used the GR antagonist RU38486 to investigate how GRs blockage affects the sensitization and CPP behavior during different phases of reward memory included acquisition, retrieval and reconsolidation. Interestingly, our results showed RU38486 has the ability to impair the acquisition, retrieval and reconsolidation of reward-based memory in CPP and sensitization behavior. But RU38486 by itself cannot induce CPP or conditioned place aversion (CPA) behavior. Our data provide a much more complete picture of the potential effects that glucocorticoids have on the reward memory of different phases and inhibit the sensitization behavior.
Authors:
Yao-Dong Fan; Hai-Chen Niu; Tanzeel Huma; Ling Li; Gui-Mei Wang; Li-Qi Xu; He Ren; Yuan-Ye Ma; Hua-Lin Yu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Dong wu xue yan jiu = Zoological research / "Dong wu xue yan jiu" bian ji wei yuan hui bian ji     Volume:  34     ISSN:  0254-5853     ISO Abbreviation:  Zool. Res.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100961499     Medline TA:  Dongwuxue Yanjiu     Country:  China    
Other Details:
Languages:  eng     Pagination:  E26-34     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, The Third Affiliated Hospital of Kunming Medical University (Yunnan Province Tumor Hospital), Kunming 650118, China. yuanma0716@vip.sina.com;yuhl308@126.com.
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