Document Detail

Blockade of renin-angiotensin system: a supplementary treatment for circumferential pulmonary vein isolation in treating persistent atrial fibrillation.
MedLine Citation:
PMID:  17475415     Owner:  NLM     Status:  MEDLINE    
The development of atrial fibrillation ablation has revolutionized the field of antiarrhythmic treatment by reducing the recurrence of atrial fibrillation (AF) significantly in patients with paroxysmal atrium fibrillation (PAF). However, the effect of ablation on the patients with persistent atrial fibrillation (PeAF) is not as good as it on PAF. Although doctors have created a series of ablation strategy, they still cannot treat PeAF effectively. This phenomenon is caused by structural remodeling and electrical remodeling of atrium during the long period of AF. Many experimental have demonstrated remodeling of atrium correlated with high level of angiotensin in atrial tissue, and blockade of renin-angiotensin system (RAS) through angiotensin-converting-enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) can reverse atrial remodeling. Clinical studies also confirmed that blockade of RAS can prevent AF effectively. Thus, for the object of treating PeAF effectively, we can combine the circumferential pulmonary vein isolation with blockade of RAS treatment, this combined strategy eliminate the trigger (pulmonary vein potential ) of AF and reverse the atrial remodeling, may be have a good effect on PeAF.
Shi-mo Dai; Shu Zhang; Jian-min Chu; Ying-hua Guo; Ke-ping Chen; Shu yuan Yao
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Publication Detail:
Type:  Journal Article     Date:  2007-05-01
Journal Detail:
Title:  Medical hypotheses     Volume:  69     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-20     Completed Date:  2007-10-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  767-72     Citation Subset:  IM    
Center of Arrhythmia Diagnosis and Treatment, Department of Cardiology, Fuwai Cardiovascular Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, PR China.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Atrial Fibrillation / drug therapy,  prevention & control*
Indoles / therapeutic use
Models, Biological
Pulmonary Veins / physiopathology*
Renin-Angiotensin System / physiology*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Indoles; 87679-37-6/trandolapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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