Document Detail

Blockade of the renin-angiotensin system. Effect on mortality in patients with left ventricular systolic dysfunction.
MedLine Citation:
PMID:  8181019     Owner:  NLM     Status:  MEDLINE    
Blockade of the renin-angiotensin-aldosterone system (RAAS) has been shown to be effective in reducing morbidity and mortality in patients with symptomatic left ventricular dysfunction. Angiotensin converting enzyme inhibitors (ACE-I) should be administered to all patients with symptomatic left ventricular dysfunction unless contraindicated or not tolerated. Although ACE-Is are effective, there is reason to believe that further blockade of the RAAS by aldosterone antagonists and/or alternative means of blocking the RAAS by use of renin inhibitors or angiotensin II receptor blocking agents may have an important role in the future. The finding in the SOLVD and SAVE trials that ACE-Is are effective in reducing recurrent ischemic events in patients with left ventricular dysfunction also holds great promise for the future, not only for patients with left ventricular dysfunction but also as a possible secondary prevention of ischemic heart disease in patients without left ventricular dysfunction.
B Pitt
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiology clinics     Volume:  12     ISSN:  0733-8651     ISO Abbreviation:  Cardiol Clin     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-14     Completed Date:  1994-06-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8300331     Medline TA:  Cardiol Clin     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  101-14     Citation Subset:  IM    
Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology,  therapeutic use*
Clinical Trials as Topic
Coronary Disease / prevention & control
Heart Failure / drug therapy*,  mortality,  physiopathology*
Renin-Angiotensin System / drug effects*
Ventricular Function, Left / drug effects*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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