Document Detail

Blockade of the pressor response to muscle ischemia by sensory nerve block in man.
MedLine Citation:
PMID:  495728     Owner:  NLM     Status:  MEDLINE    
Differential nerve block from peridural anesthesia was used to determine a) if the pressor response to muscle ischemia in man is caused by stimulation of small sensory nerve fibers and b) if these fibers contribute to cardiovascular-respiratory responses during dynamic exercise. Four men exercised at 50-100 W for 5 min. Muscle ischemia and a sustained pressor response were produced by total circulatory occlusion of both legs beginning 30 s before the end of exercise and continuing for 3 min postexercise. During regression of full motor and sensory block, motor strength recovered while sensory block continued; the pressor response was blocked as long as sensory anesthesia persisted (two subjects). During blockade of the pressor response, cardiovascular-respiratory responses to exercise gradually returned from augmented to normal (preblock) levels. Sensory blockade was incomplete in two subjects and the pressor response was not fully blocked. We conclude that stimulation of small sensory fibers during ischemia elicits the pressor response, but that these fibers appear not to contribute to cardiovascular-respiratory responses during mild dynamic exercise with adequate blood flow.
P R Freund; L B Rowell; T M Murphy; S F Hobbs; S H Butler
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  237     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1979-12-27     Completed Date:  1979-12-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H433-9     Citation Subset:  IM; S    
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MeSH Terms
Blood Pressure*
Chemoreceptor Cells / physiology*
Heart / physiology
Heart Rate
Muscles / blood supply*,  innervation
Nerve Block*
Physical Exertion

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