Document Detail


Blockade of the passive cell death pathway does not prevent tolerance induction to islet grafts.
MedLine Citation:
PMID:  17353789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: T-cell apoptosis is an important regulatory mechanism in transplant tolerance. The aim of this study was to identify specific apoptotic molecules important for tolerance induction.
METHODS: Mice expressing the human Bcl-2 molecule in T cells or Bim -/- mice were used as islet allograft or rat islet xenograft recipients and treated with CTLA4-Fc and MR1 costimulation blockade.
RESULTS: hBcl-2 transgenic mice and Bim -/- accepted islet allografts and rat islet xenografts for more than 100 days, similar to wildtype controls. Changes in the dose of the CTLA4-Fc and MR1 did not lead to differences in graft survival and there were no differences in the percentage of CD4+ T cells expressing Fas, CD25, or undergoing apoptosis.
CONCLUSIONS: Inhibition of the passive cell death pathway in T cells did not block tolerance induction, suggesting that the mechanism by which apoptosis regulates the alloimmune response is more complex than first thought.
Authors:
Anne M Lehnert; Lisa Murray-Segal; Peter J Cowan; Anthony J d'Apice; Philip J O'Connell
Related Documents :
7489709 - Apoptosis by a cytosolic extract from fas-activated cells.
16461549 - Luteinizing hormone inhibits fas-induced apoptosis in ovarian surface epithelial cell l...
12100609 - Roles of tumor necrosis factor-alpha-receptor type 1 and fas in the helicobacter pylori...
19107989 - A critical role for fas/cd-95 dependent signaling pathways in the pathogenesis of hyper...
14698509 - Cordyceps sinensis extracts do not prevent fas-receptor and hydrogen peroxide-induced t...
9373219 - Activation of t-cells through an antigen-independent alternative pathway induces precoc...
21551359 - Recruitment of dendritic cells is responsible for intestinal epithelial damage in the p...
21798349 - Dietary phytochemicals and their potential effects on obesity: a review.
20937129 - Tgfβ signaling in the brain increases with aging and signals to astrocytes and innate ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transplantation     Volume:  83     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-13     Completed Date:  2007-04-20     Revised Date:  2013-05-24    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  653-5     Citation Subset:  IM    
Affiliation:
Centre for Transplant and Renal Research, Westmead Millennium Institute, University of Sydney at Westmead Hospital, New South Wales, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Cell Death / physiology*
Graft Survival
Humans
Immune Tolerance*
Immunoconjugates / genetics
Islets of Langerhans Transplantation / immunology*
Mice
Mice, Transgenic
Proto-Oncogene Proteins c-bcl-2 / genetics
Rats
Chemical
Reg. No./Substance:
0/Immunoconjugates; 0/Proto-Oncogene Proteins c-bcl-2; 7D0YB67S97/abatacept

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Immunophenotype of infiltrating cells in protocol renal allograft biopsies from tacrolimus-versus cy...
Next Document:  Growth factor-induced mobilization of dendritic cells in kidney and liver of rhesus macaques: implic...