Document Detail


Blockade of dopamine receptors reverses the behavioral effects of endogenous enkephalins in the Nucleus caudatus but not in the Nucleus accumbens: differential involvement of delta and mu opioid receptors.
MedLine Citation:
PMID:  2572028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously (Daugé et al. 1988) demonstrated that injection of the mu agonist [D-Ala2, MePhe4, Gly-ol5]-enkephalin (DAGO) or the delta agonist [D-Thr2, Leu5]-enkephalyl-Thr6 (DTLET) into the rat Nucleus accumbens (N.Acc.), or Nucleus caudatus (N.Caud.) induced a hypoactivity followed by hyperactivity 150 min later in the case of the mu agonist and a hyperactivity in the case of the delta agonist. Moreover, naloxone reversible delta-type responses were obtained by local infusion of kelatorphan, ([(R)-3(N-hydroxylcarboxamido-2-benzylpropanoyl)-L-alanine]), a complete inhibitor of enkephalin catabolism, suggesting a tonic control of the behavioral activity of rat by the endogenous opioid peptides. In this work, the putative involvement of the dopaminergic system in these behavioral responses was investigated by using the DA antagonist thioproperazine. In the N.Acc., the behavioral effects of kelatorphan or of mu or delta agonists were not altered by thioproperazine-induced blockade of dopamine receptors. In contrast, the hyperactivity produced by DTLET or by kelatorphan in the N.Caud. was reversed by thioproperazine while the time-dependent biphasic effect resulting from DAGO injection remained unaffected by the DA antagonist. This blocking effect of thioproperazine is in agreement with the previously described delta-selective enhancement of the release of newly synthesized DA in the striatum but not in the N.Acc.
Authors:
V Daugé; P Rossignol; B P Roques
Related Documents :
2572028 - Blockade of dopamine receptors reverses the behavioral effects of endogenous enkephalin...
1327838 - Kappa 3 opiate receptor binding in the mouse and rat.
7680938 - Morphological evidence for the activation of descending modulatory control by nocicepti...
379628 - Delta 1-tetrahydrocannabinol and 1 alpha, 2 alpha-epoxyhexahydrocannabinol: mutagenicit...
3764778 - The antiestrogen ly117018 is estrogenic in the fetal rat.
2482448 - Effect of ruthenium red on responses mediated by activation of capsaicin-sensitive nerv...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychopharmacology     Volume:  99     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1989  
Date Detail:
Created Date:  1989-11-15     Completed Date:  1989-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  168-75     Citation Subset:  IM    
Affiliation:
Laboratoire de Pharmacologie, UER des Sciences Pharmaceutiques et Biologiques, Paris, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Apomorphine / pharmacology
Behavior, Animal / drug effects*
Caudate Nucleus / drug effects,  physiology*
Dipeptides / pharmacology
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
Enkephalins / antagonists & inhibitors,  pharmacology,  physiology*
Male
Microinjections
Motor Activity / drug effects
Nucleus Accumbens / drug effects,  physiology*
Oligopeptides / pharmacology
Phenothiazines / pharmacology
Rats
Rats, Inbred Strains
Receptors, Dopamine / drug effects*,  physiology
Receptors, Opioid / physiology
Receptors, Opioid, delta
Receptors, Opioid, mu
Septal Nuclei / physiology*
Chemical
Reg. No./Substance:
0/Dipeptides; 0/Enkephalins; 0/Oligopeptides; 0/Phenothiazines; 0/Receptors, Dopamine; 0/Receptors, Opioid; 0/Receptors, Opioid, delta; 0/Receptors, Opioid, mu; 100929-53-1/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; 58-00-4/Apomorphine; 85286-38-0/deltakephalin; 92175-57-0/kelatorphan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  SCH 23390 blocks drug-conditioned place-preference and place-aversion: anhedonia (lack of reward) or...
Next Document:  Acute laryngeal dystonic reactions to neuroleptics.