Document Detail


Blockade of distal nephron sodium transport attenuates pressure natriuresis in dogs.
MedLine Citation:
PMID:  8206590     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sodium excretory responses (UNaV) to acute changes in renal arterial pressure (RAP) during blockade of distal nephron sodium transport were evaluated in seven sodium-replete anesthetized dogs. The major distal sodium entry pathways were blocked by intrarenal infusion of amiloride (AM, 10(-5) mol/L) and bendroflumethiazide (BZ, 10(-6) mol/L). Infusion of AM plus BZ caused slight increases in renal blood flow (RBF, 4.1 +/- 0.5 to 4.6 +/- 0.4 mL.min-1.g-1; P < .001) but no changes in glomerular filtration rate (GFR, 0.96 +/- 0.05 to 1.01 +/- 0.07 mL.min-1.g-1; P = NS) or autoregulatory efficiency of RBF and GFR. There were significant increases in UNaV (2.7 +/- 0.7 to 5.2 +/- 0.6 mumol.min-1.g-1) and fractional excretion of sodium (FENa, 1.8 +/- 0.4% to 3.5 +/- 0.3%) and decreases in potassium excretion (0.59 +/- 0.10 to 0.35 +/- 0.06 mumol.min-1.g-1) during AM plus BZ infusion. During the control period and during repeat measurements in time control studies, decreases in RAP (150 to 100 mm Hg) elicited the usual decreases in UNaV (slope, 0.022 +/- 0.007 mumol.min-1.g-1.mm Hg-1; P < .01). After administration of AM plus BZ, there was a marked attenuation of the pressure-natriuretic responses, and the slopes of the RAP versus UNaV and RAP versus FENa relations at RAP levels above 100 mm Hg were not significantly different from zero. However, the pressure-natriuresis response was maintained at arterial pressure between 75 and 100 mm Hg.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
D S Majid; L G Navar
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  23     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-11     Completed Date:  1994-07-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1040-5     Citation Subset:  IM    
Affiliation:
Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112.
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MeSH Terms
Descriptor/Qualifier:
Amiloride / pharmacology
Animals
Arginine / analogs & derivatives,  pharmacology
Bendroflumethiazide / pharmacology
Biological Transport
Blood Pressure*
Dogs
Drug Combinations
Female
Hemodynamics / drug effects
Homeostasis / drug effects
Kidney / drug effects
Male
Natriuresis*
Nephrons / metabolism*
Nitroarginine
Plasma Substitutes / pharmacology
Renal Circulation / drug effects
Sodium / metabolism*
Grant Support
ID/Acronym/Agency:
HL-18426/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Drug Combinations; 0/Plasma Substitutes; 2149-70-4/Nitroarginine; 2609-46-3/Amiloride; 73-48-3/Bendroflumethiazide; 74-79-3/Arginine; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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