Document Detail


Blockade of central nicotine acetylcholine receptor signaling attenuate ghrelin-induced food intake in rodents.
MedLine Citation:
PMID:  20933579     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Here we sought to determine whether ghrelin's central effects on food intake can be interrupted by nicotine acetylcholine receptor (nAChR) blockade. Ghrelin regulates mesolimbic dopamine neurons projecting from the ventral tegmental area (VTA) to the nucleus accumbens, partly via cholinergic VTA afferents originating in the laterodorsal tegmental area (LDTg). Given that these cholinergic projections to the VTA have been implicated in natural as well as drug-induced reinforcement, we sought to investigate the role of cholinergic signaling in ghrelin-induced food intake as well as fasting-induced food intake, for which endogenous ghrelin has been implicated. We found that i.p. treatment with the non-selective centrally active nAChR antagonist, mecamylamine decreased fasting-induced food intake in both mice and rats. Moreover, central administration of mecamylamine decreased fasting-induced food intake in rats. I.c.v. ghrelin-induced food intake was suppressed by mecamylamine i.p. but not by hexamethonium i.p., a peripheral nAChR antagonist. Furthermore, mecamylamine i.p. blocked food intake following ghrelin injection into the VTA. Expression of the ghrelin receptor, the growth hormone secretagogue receptor 1A, was found to co-localize with choline acetyltransferase, a marker of cholinergic neurons, in the LDTg. Finally, mecamylamine treatment i.p. decreased the ability of palatable food to condition a place preference. These data suggest that ghrelin-induced food intake is partly mediated via nAChRs and that nicotinic blockade decreases the rewarding properties of food.
Authors:
S L Dickson; E Hrabovszky; C Hansson; E Jerlhag; M Alvarez-Crespo; K P Skibicka; C S Molnar; Z Liposits; J A Engel; E Egecioglu
Related Documents :
17255209 - Centrally and peripherally administered ghrelin potently inhibits water intake in rats.
15748719 - Different effects of peripheral and central ghrelin on regulation of food intake in the...
9854049 - Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropepti...
11246039 - Regulatory peptides and control of food intake in non-mammalian vertebrates.
10958999 - Melanocortin signaling is decreased during neurotoxin-induced transient hyperphagia and...
12069929 - Principles for interpreting interactions among the multiple systems that influence food...
20026139 - Food-related family lifestyle associated with fruit and vegetable consumption among you...
17155139 - Mutually catalyzed birth of population and assets in exchange-driven growth.
22069659 - Food poisoning and staphylococcus aureus enterotoxins.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-08
Journal Detail:
Title:  Neuroscience     Volume:  171     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1180-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Medicinaregatan 11, SE-405 30 Gothenburg, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of low-voltage-activated calcium current on the firing pattern alterations induced by hypothyro...
Next Document:  Glial cell line-derived neurotrophic factor is crucial for long-term maintenance of the nigrostriata...