Document Detail

Blockade of angiotensin II improves hyperthyroid induced abnormal atrial electrophysiological properties.
MedLine Citation:
PMID:  21545815     Owner:  NLM     Status:  Publisher    
BACKGROUND: Previous studies reported that RAS inhibitors prevented atrial fibrillation by improving atrial electrical and structural remodeling. However, the effect of RAS inhibitors on the substrates of atrial fibrillation (AF) underlying hyperthyroid is unclear. METHODS: Forty rabbits were assigned to four groups: sham group, thyroxine group, benazepril group and irbesartan group (10 per group). The atrial effective refractory period (AERP) was measured. The physiologic rate adaptation and the AF vulnerability were evaluated. The real-time PCR, Western blot or fluorescent immunohistochemistry was performed to detect the expression of AF related Ca+, K+ channel and gap junction. RESULTS: No significant difference was found in AERP among the thyroxine group, benazepril group and irbesartan group (75.13±5.41ms vs. 76.63±4.44ms, 79±4.95ms, P=0.28). However, benazepril or irbesartan could reduce AF vulnerability underlying hyperthyroid (75% vs. 37%, 44%, for thyroxine group, benazepril group and irbesartan group, respectively), and significantly improved physiologic rate adaptation of the AERP. Furthermore, both drugs significantly reduced L-Ca(2+) channel related subunits (α1C or α1D) and interstitial fibrosis (17.1±2.2% vs. 12.3±1.8, 11.7±1.2%, P<0.01, for thyroxine group, benazepril group and irbesartan group, respectively), increased lateral/polar connection of Cx43 (1.04±0.16 vs. 1.33±0.29,1.28±0.25, P<0.01, for thyroxine group, benazepril group and irbesartan group, respectively) and improved the abnormal distribution of gap junctions (Cx40, Cx43) underlying hyperthyroid. CONCLUSION: Blockade of angiotensin II could improve abnormal atrial electrophysiological properties and further reduce AF vulnerability by extenuating ion channel, gap junction and structural remodeling in experimental thyrotoxic rabbits.
Peilin Xiao; Chonghan Gao; Jinqi Fan; Huaan Du; Yi Long; Yuehui Yin
Related Documents :
21430925 - Lead-induced hepatotoxicity and evaluation of certain anti-stress adaptogens in poultry.
21112165 - Anaplasmosis in dogs: the relation of haematological, biochemical and clinical alterati...
21121755 - The influence of approach side on facet preservation in microscopic bilateral decompres...
21298835 - Effectiveness of packed rice-oral rehydration solution among children with acute watery...
19865795 - A prospective study of hip revision surgery using the exeter long-stem prosthesis: func...
16430125 - Acupuncture and self acupuncture for long-term treatment of vasomotor symptoms in cance...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-2
Journal Detail:
Title:  Regulatory peptides     Volume:  -     ISSN:  1873-1686     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The relationship between adiponectin, ageing and renal function in a bi-ethnic sample.
Next Document:  Aldosterone induction of hepatic stellate cell contraction through activation of RhoA/ROCK-2 signali...