| Blockade of the TP receptor attenuates the exercise pressor reflex in decerebrated rats with chronic femoral artery occlusion. | |
| | |
MedLine Citation:
|
PMID: 21856914 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Cyclooxygenase metabolites stimulate or sensitize group III and IV muscle afferents, which comprise the sensory arm of the exercise pressor reflex. The thromboxane (TP) receptor binds several of these metabolites, whose concentrations in the muscle interstitium are increased by exercise under freely perfused conditions and even more so under ischemic conditions, which occur in peripheral artery disease. We showed that the exercise pressor reflex is greater in rats with simulated peripheral artery disease than in rats with freely perfused limbs. These findings prompted us to test the hypothesis that the TP receptor contributes to the exaggerated exercise pressor reflex occurring in a rat model of peripheral artery disease. We compared the cardiovascular responses to static contraction and stretch before and after femoral arterial injections of daltroban (80 μg), a TP receptor antagonist. We performed these experiments in decerebrate rats whose femoral arteries were ligated 72 hours prior to the experiment (a model of simulated peripheral artery disease) and in control rats whose hind limbs were freely perfused. Daltroban reduced the pressor response to static contraction in both freely perfused (n=6; before: Δ 12 ± 2 mmHg, after: Δ 6 ± 2 mmHg, P=0.024) and 72 hour ligated rats (n=10; before: Δ 25 ± 3 mmHg, after: Δ 7 ± 4 mmHg, P=0.001). Likewise, daltroban reduced the pressor response to stretch in the freely perfused group (n=9; before: Δ 30 ± 3 mmHg, after: Δ 17 ± 3 mmHg, P=<.0001) and in the ligated group (n=11; before: Δ 37 ± 5 mmHg, after: Δ 23 ± 3 mmHg, P= 0.016). Intravenous injections of daltroban had no effect on the pressor response to contraction. We conclude that the TP receptor contributes to the pressor responses evoked by contraction and stretch in both freely perfused rats and rats with simulated peripheral artery disease. |
| | |
Authors:
|
Anna K Leal; Jennifer L McCord; Hirotsugu Tsuchimochi; Marc P Kaufman |
Related Documents
:
|
2585534 - Acute pulmonary response in healthy, nonsmoking adults to inhalation of formaldehyde an... 17258484 - Sub-lethal ammonia toxicity in largemouth bass. 3168964 - Does suggestibility modify acute reactions to passive cigarette smoke exposure? 7320774 - Otologic referral in industrial hearing conservation programs. 20339244 - Effect of acute exercise on the levels of salivary cortisol, tumor necrosis factor-alph... 21781214 - Registered nurses' beliefs of the benefits of exercise, their exercise behaviour and th... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-19 |
Journal Detail:
|
Title: American journal of physiology. Heart and circulatory physiology Volume: - ISSN: 1522-1539 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-8-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1Penn State University. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: SIRT1 mediated acute cardioprotection.
Next Document: Calcium sensitization of cardiac myofilament proteins contributes to exercise training-enhanced myoc...