Document Detail

Block to DNA replication in meiotic maturation: a unified view for a robust arrest of cell cycle in oocytes and somatic cells.
MedLine Citation:
PMID:  12655638     Owner:  NLM     Status:  MEDLINE    
Under certain conditions, the cell cycle can be arrested for a long period of time. Vertebrate oocytes are arrested at G(2) phase, while somatic cells arrest at G(0) phase. In both cells, nuclei have lost the ability to initiate DNA synthesis. In a pair of recently published papers,[1,2] Méchali and colleagues and Coué and colleagues have clarified how frog oocytes prevent untimely DNA synthesis during the long G(2) arrest. Intriguingly, they found only Cdc6 is responsible for the inability of immature oocytes to replicate DNA. Cdc6 is a key component for replication licensing, and for G(0) cells to re-enter the proliferative stage. Strikingly similar strategies for preventing the untimely replication in both cells suggest that the suppression of replication licensing is a universal mechanism for securing the prolonged arrest of the cell cycle.
Yumiko Kubota; Haruhiko Takisawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BioEssays : news and reviews in molecular, cellular and developmental biology     Volume:  25     ISSN:  0265-9247     ISO Abbreviation:  Bioessays     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-25     Completed Date:  2003-07-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8510851     Medline TA:  Bioessays     Country:  United States    
Other Details:
Languages:  eng     Pagination:  313-6     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley Periodicals, Inc.
Department of Biology, Osaka University, Toyonaka, Osaka 560-0043, Japan.
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MeSH Terms
Cell Cycle / physiology*
Chromosomal Proteins, Non-Histone / metabolism
DNA Replication*
Meiosis / physiology*
Oocytes / physiology*
Xenopus Proteins*
Xenopus laevis
Reg. No./Substance:
0/Cdc6 protein, Xenopus; 0/Chromosomal Proteins, Non-Histone; 0/Xenopus Proteins

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