Document Detail

A blind circadian clock in cavefish reveals that opsins mediate peripheral clock photoreception.
MedLine Citation:
PMID:  21909239     Owner:  NLM     Status:  MEDLINE    
The circadian clock is synchronized with the day-night cycle primarily by light. Fish represent fascinating models for deciphering the light input pathway to the vertebrate clock since fish cell clocks are regulated by direct light exposure. Here we have performed a comparative, functional analysis of the circadian clock involving the zebrafish that is normally exposed to the day-night cycle and a cavefish species that has evolved in perpetual darkness. Our results reveal that the cavefish retains a food-entrainable clock that oscillates with an infradian period. Importantly, however, this clock is not regulated by light. This comparative study pinpoints the two extra-retinal photoreceptors Melanopsin (Opn4m2) and TMT-opsin as essential upstream elements of the peripheral clock light input pathway.
Nicola Cavallari; Elena Frigato; Daniela Vallone; Nadine Fröhlich; Jose Fernando Lopez-Olmeda; Augusto Foà; Roberto Berti; Francisco Javier Sánchez-Vázquez; Cristiano Bertolucci; Nicholas S Foulkes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-06
Journal Detail:
Title:  PLoS biology     Volume:  9     ISSN:  1545-7885     ISO Abbreviation:  PLoS Biol.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-12     Completed Date:  2012-01-05     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101183755     Medline TA:  PLoS Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1001142     Citation Subset:  IM    
Department of Biology and Evolution, University of Ferrara, Ferrara, Italy.
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MeSH Terms
Cell Line
Circadian Clocks / physiology*
Circadian Rhythm / physiology*
Feeding Behavior
Gene Expression
Opsins / genetics,  metabolism*
Photic Stimulation
Photoreceptor Cells, Vertebrate / physiology*
Rod Opsins / genetics,  metabolism
Zebrafish / physiology*
Reg. No./Substance:
0/Opsins; 0/Rod Opsins; 0/melanopsin
Comment In:
PLoS Biol. 2011 Sep;9(9):e1001141   [PMID:  21909238 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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