| Blimp-1 siRNA inhibits B cell differentiation and prevents the development of lupus in mice. | |
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MedLine Citation:
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PMID: 23220434 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cumulative evidence suggest that B-lymphocytes play a role in the development of systemic lupus erythematosus (SLE). Thus, the therapeutic approach targeting specific B cells provides a promising way to treat SLE. Blimp-1 (B lymphocyte induced maturation protein), a transcriptional factor, controls the terminal differentiation of mature B cells to plasma cells. To explore the potential of Blimp-1 in the SLE development, we constructed the adenovirus encoding Blimp-1 siRNA, and injected it into BWF1 lupus mice. The results demonstrated that Blimp-1 siRNA decreased the Blimp-1 expression of B cells by regulating XBP-1 (X Box binding protein-1), BCMA (B-cell maturation antigen) expression through c-myc pathway. In addition, Blimp-1 siRNA eliminated anti-dsDNA antibody-producing plsma cells, reduced serum anti-dsDNA antibody levels and impeded the development of lupus. Therefore, our data provide the insight into the mechanism of Blimp-1 in SLE development and might represent a promising therapeutic strategy for autoantibody- mediated diseases. |
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Authors:
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Zhongqi Zhou; Yueqin Ren; Zhao Hu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-6 |
Journal Detail:
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Title: Human immunology Volume: - ISSN: 1879-1166 ISO Abbreviation: Hum. Immunol. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8010936 Medline TA: Hum Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
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Department of nephrology, Qilu Hospital, Shandong university, Jinan, Shandong 250012, China; Department of nephrology, Linyi People's Hospital, Linyi, Shandong 276000, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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