Document Detail

Blepharoconjunctivitis: a side effect of 13-cis-retinoic acid therapy for dermatologic diseases.
MedLine Citation:
PMID:  161804     Owner:  NLM     Status:  MEDLINE    
Blepharoconjunctivitis developed as a side-effect of treatment of patients with basal cell carcinomas, keratinizing dermatoses, and cystic acne with oral 13-cis-retinoic acid. Forty-two of the 97 dermatologic patients had signs and symptoms of blepharoconjunctivitis that were dose related and abated one week after discontinuation of the medication. About half of the patients had a history of similar symptoms prior to treatment. Staphylococcus aureus was present in eye cultures of 73% to 79% of the patients, whether symptomatic or not. Patients whose clinical appearance was that of staphylococcal blepharoconjunctivitis and whose cultures grew S aureus were successfully treated with topical erythromycin ointment to the lids even while being treated with the 13-cis-retinoic acid.
H J Blackman; G L Peck; T G Olsen; D R Bergsma
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ophthalmology     Volume:  86     ISSN:  0161-6420     ISO Abbreviation:  Ophthalmology     Publication Date:  1979 May 
Date Detail:
Created Date:  1980-07-26     Completed Date:  1980-07-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  753-9     Citation Subset:  IM    
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MeSH Terms
Acne Vulgaris / drug therapy
Blepharitis / chemically induced*,  drug therapy
Carcinoma, Basal Cell / drug therapy
Conjunctivitis / chemically induced*,  drug therapy
Erythromycin / therapeutic use
Eyelid Diseases / chemically induced*
Keratosis / drug therapy
Skin Diseases / drug therapy*
Skin Neoplasms / drug therapy
Staphylococcal Infections* / drug therapy
Tretinoin / adverse effects*,  therapeutic use
Reg. No./Substance:
114-07-8/Erythromycin; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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