| Bleomycin and subsequent anaesthesia: a retrospective study at Vancouver General Hospital. | |
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MedLine Citation:
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PMID: 6160899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A retrospective review was made of 20 surgical procedures in 14 patients with testicular carcinoma, previously treated with bleomycin chemotherapy, to evaluate the incidence of postoperative pulmonary complications. Other studies have suggested an increased rate of pulmonary complications, including fatal respiratory failure, when inspired oxygen fraction (FIO2) exceeds 0.3 during or after operation. There is a suggestion that bleomycin may sensitize the lungs to the effect of oxygen, leading to oxygen toxicity. This study involved patients whose inspired oxygen fraction ranged from 0.3 to 1.0 and only one non-fatal pulmonary complication occurred. The risks of anaesthesia following bleomycin are discussed with particular reference to possible enhanced oxygen toxicity. |
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Authors:
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M J Douglas; C M Coppin |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Canadian Anaesthetists' Society journal Volume: 27 ISSN: 0008-2856 ISO Abbreviation: Can Anaesth Soc J Publication Date: 1980 Sep |
Date Detail:
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Created Date: 1981-03-24 Completed Date: 1981-03-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0371163 Medline TA: Can Anaesth Soc J Country: CANADA |
Other Details:
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Languages: eng Pagination: 449-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia
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adverse effects* Bleomycin / adverse effects* Humans Male Middle Aged Oxygen / toxicity Postoperative Complications / etiology* Respiratory Insufficiency / etiology* Retrospective Studies Testicular Neoplasms / drug therapy, surgery |
| Chemical | |
Reg. No./Substance:
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11056-06-7/Bleomycin; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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