Document Detail

Bleomycin and subsequent anaesthesia: a retrospective study at Vancouver General Hospital.
MedLine Citation:
PMID:  6160899     Owner:  NLM     Status:  MEDLINE    
A retrospective review was made of 20 surgical procedures in 14 patients with testicular carcinoma, previously treated with bleomycin chemotherapy, to evaluate the incidence of postoperative pulmonary complications. Other studies have suggested an increased rate of pulmonary complications, including fatal respiratory failure, when inspired oxygen fraction (FIO2) exceeds 0.3 during or after operation. There is a suggestion that bleomycin may sensitize the lungs to the effect of oxygen, leading to oxygen toxicity. This study involved patients whose inspired oxygen fraction ranged from 0.3 to 1.0 and only one non-fatal pulmonary complication occurred. The risks of anaesthesia following bleomycin are discussed with particular reference to possible enhanced oxygen toxicity.
M J Douglas; C M Coppin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Canadian Anaesthetists' Society journal     Volume:  27     ISSN:  0008-2856     ISO Abbreviation:  Can Anaesth Soc J     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1981-03-24     Completed Date:  1981-03-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0371163     Medline TA:  Can Anaesth Soc J     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  449-52     Citation Subset:  IM    
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MeSH Terms
Anesthesia / adverse effects*
Bleomycin / adverse effects*
Middle Aged
Oxygen / toxicity
Postoperative Complications / etiology*
Respiratory Insufficiency / etiology*
Retrospective Studies
Testicular Neoplasms / drug therapy,  surgery
Reg. No./Substance:
11056-06-7/Bleomycin; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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