Document Detail


Bleomycin A5 plus dexamethasone for control of growth in infantile parotid hemangiomas.
MedLine Citation:
PMID:  19451005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to evaluate the efficacy of bleomycin A5 (pingyangmycin) plus dexamethasone for control of growth in infantile parotid hemangiomas. STUDY DESIGN: We reviewed and analyzed the data of 31 cases undergoing therapy of intralesional injection with small-dosage and low-concentration bleomycin A5 plus dexamethasone between June 2004 and October 2007. Clinical manifestations, image characteristics, and therapeutic outcomes were reviewed. The therapeutic outcomes were evaluated by physical examination, photographs, and Doppler ultrasonography. The follow-up was from 6 months to 3 years after ending treatment. RESULTS: Twenty-five patients (80.6%) had a response rate greater than 90% reduction in tumor size. Three patients (9.7%) had a response rate between 75% and 90% reduction in tumor size. Another 3 patients (9.7%) had a response rate between 50% and 75% reduction in size. No patients had less than a 50% response rate. There was no recurrence, allergic reaction, pulmonary fibrosis, fever, or other complication during or after the course of treatment. CONCLUSIONS: The controlling therapy with small-dosage and low-concentration bleomycin A5 plus dexamethasone can treat the parotid hemangiomas of infants effectively, especially for lesions in the early phase and proliferative phase. Early control and long-term observation are the key aspects of treatment.
Authors:
Yaowu Yang; Moyi Sun; Xiaobing Cheng; Xiaoguang Hu; Pu Zhang; Qin Ma; Jianhu Li; Lei Tian; Delin Lei
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-17
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  108     ISSN:  1528-395X     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-22     Completed Date:  2009-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62-9     Citation Subset:  D; IM    
Affiliation:
Department of Oral and Maxillofacial Surgery, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi, China. yangyaowu_1@sina.com
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MeSH Terms
Descriptor/Qualifier:
Antibiotics, Antineoplastic / administration & dosage*
Antineoplastic Agents, Hormonal / administration & dosage*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Bleomycin / administration & dosage,  analogs & derivatives*
Contrast Media
Dexamethasone / administration & dosage*
Female
Follow-Up Studies
Gadolinium DTPA / diagnostic use
Hemangioma / drug therapy*
Humans
Infant
Injections, Intralesional
Magnetic Resonance Imaging
Male
Parotid Neoplasms / drug therapy*
Photography
Physical Examination
Remission Induction
Treatment Outcome
Ultrasonography, Doppler
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Antineoplastic Agents, Hormonal; 0/Contrast Media; 11056-06-7/Bleomycin; 11116-32-8/bleomycetin; 50-02-2/Dexamethasone; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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