Document Detail

Blending chitosan with polycaprolactone: porous scaffolds and toxicity.
MedLine Citation:
PMID:  17703475     Owner:  NLM     Status:  MEDLINE    
The preparation and characterization of porous scaffolds from chitosan-PCL blends by freeze extraction, freeze gelation and freeze drying is reported. Using freeze extraction, stable structures were obtained only from PCL, but these were not porous. No stable scaffolds were obtained using the freeze gelation process. Stable scaffolds of chitosan/PCL mixtures could not be obtained using 77% acetic acid by any of these techniques. With 25% aqueous acetic acid, stable scaffolds of chitosan/PCL mixtures were obtained by the freeze drying technique. The stability and pore morphology of freeze dried scaffolds were dependent on the relative mass ratio of chitosan and PCL. A chorioallantoic membrane assay showed that formed 3D chitosan/PCL mixtures were not toxic to vasculature.
Aparna R Sarasam; Afshan I Samli; Linda Hess; Michael A Ihnat; Sundararajan V Madihally
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Macromolecular bioscience     Volume:  7     ISSN:  1616-5187     ISO Abbreviation:  Macromol Biosci     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2008-01-22     Revised Date:  2008-08-14    
Medline Journal Info:
Nlm Unique ID:  101135941     Medline TA:  Macromol Biosci     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1160-7     Citation Subset:  IM    
School of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USA.
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MeSH Terms
Acetic Acid / chemistry
Allantois / metabolism
Biocompatible Materials / chemistry*,  metabolism
Chitosan / chemistry*,  metabolism
Freeze Drying
Materials Testing
Polyesters / chemistry*,  metabolism
Surface Properties
Tissue Engineering
Grant Support
1R21DK074858-01A2/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Biocompatible Materials; 0/Polyesters; 24980-41-4/polycaprolactone; 64-19-7/Acetic Acid; 9012-76-4/Chitosan

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