| Blending chitosan with polycaprolactone: porous scaffolds and toxicity. | |
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MedLine Citation:
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PMID: 17703475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The preparation and characterization of porous scaffolds from chitosan-PCL blends by freeze extraction, freeze gelation and freeze drying is reported. Using freeze extraction, stable structures were obtained only from PCL, but these were not porous. No stable scaffolds were obtained using the freeze gelation process. Stable scaffolds of chitosan/PCL mixtures could not be obtained using 77% acetic acid by any of these techniques. With 25% aqueous acetic acid, stable scaffolds of chitosan/PCL mixtures were obtained by the freeze drying technique. The stability and pore morphology of freeze dried scaffolds were dependent on the relative mass ratio of chitosan and PCL. A chorioallantoic membrane assay showed that formed 3D chitosan/PCL mixtures were not toxic to vasculature. |
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Authors:
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Aparna R Sarasam; Afshan I Samli; Linda Hess; Michael A Ihnat; Sundararajan V Madihally |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Macromolecular bioscience Volume: 7 ISSN: 1616-5187 ISO Abbreviation: Macromol Biosci Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-17 Completed Date: 2008-01-22 Revised Date: 2008-08-14 |
Medline Journal Info:
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Nlm Unique ID: 101135941 Medline TA: Macromol Biosci Country: Germany |
Other Details:
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Languages: eng Pagination: 1160-7 Citation Subset: IM |
Affiliation:
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School of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acid
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chemistry Allantois / metabolism Animals Biocompatible Materials / chemistry*, metabolism Chickens Chitosan / chemistry*, metabolism Freeze Drying Materials Testing Polyesters / chemistry*, metabolism Porosity Surface Properties Tissue Engineering |
| Grant Support | |
ID/Acronym/Agency:
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1R21DK074858-01A2/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Polyesters; 24980-41-4/polycaprolactone; 64-19-7/Acetic Acid; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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