Document Detail

Bleeding predictors in factor-XI-deficient patients.
MedLine Citation:
PMID:  9491269     Owner:  NLM     Status:  MEDLINE    
Bleeding in factor-XI-deficient patients is mainly injury-related. Parameters influencing bleeding particularly in patients with minor factor XI deficiency have not been defined. We utilized a logistic regression model to analyze parameters influencing bleeding tendency in subjects from 45 families with factor XI deficiency. Bleeding manifestations were documented in 58% of 26 homozygous or doubly heterozygous factor-XI-deficient patients, in 20% of 46 heterozygous factor-XI-deficient patients and in 9% of 47 family members with a normal factor XI genotype. Odds ratios for bleeding in homozygotes or double heterozygotes were 13 and in heterozygotes 2.6 with 95% confidence intervals of 3.8-45 and 0.8-9.0, respectively. Bleeding correlated negatively with factor XI level (r = -0.36, P = 0.0001) with major factor XI deficiency being a strong predictor of bleeding (P = 0.011). Minor factor XI deficiency and blood group O slightly contributed to bleeding. Although factor VIII and factor XI levels were correlated (r = 0.48, P = 0.0001), levels of factor VIII and von Willebrand factor were not predictors of bleeding. Bleeding was more common following operative procedure involving mucosal membranes (P < 0.01). The designed model enabled prediction of bleeding manifestations with an overall accuracy of 78% and 82% in heterozygotes.
B Brenner; A Laor; H Lupo; A Zivelin; N Lanir; U Seligsohn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  8     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-04-15     Completed Date:  1998-04-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  511-5     Citation Subset:  IM    
Thrombosis & Hemostasis Unit, Rambam Medical Center, Technion, Haifa, Israel.
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MeSH Terms
Case-Control Studies
Factor VIII / metabolism
Factor XI / genetics,  metabolism
Factor XI Deficiency / complications*
Hemorrhage / diagnosis*,  etiology
Logistic Models
Predictive Value of Tests
Regression Analysis
von Willebrand Factor / metabolism
Reg. No./Substance:
0/von Willebrand Factor; 9001-27-8/Factor VIII; 9013-55-2/Factor XI

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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