Document Detail

Bleeding patterns and menstrual-related symptoms with the continuous use of a contraceptive combination of ethinylestradiol and drospirenone: a randomized study.
MedLine Citation:
PMID:  20159177     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The objective of this study was to compare bleeding patterns of women using a contraceptive combination of 30 mcg ethinylestradiol (EE) and 3 mg drospirenone (DRSP) continuously or cyclically. Menstrual-related symptoms were also evaluated. STUDY DESIGN: This open, prospective, randomized study evaluated 78 women using the EE/DRSP combination continuously for 168 days or for six 28-day cycles, each followed by a 7-day hormone-free interval. A diary with pre-established scales was used to assess the frequency and intensity of bleeding and menstrual-related symptoms. RESULTS: Amenorrhea increased with continuous use; 62.2% of women with continuous use were amenorrheic at the end of treatment (95% CI: 46.6-77.8%). Dysmenorrhea, headache, acne, nausea, edema and increased appetite improved significantly in the continuous-use group, and mastalgia and edema in the cyclic-use group (p<.05). Six subjects in the continuous-use group (15.4%) and three in the cyclic-use group (7.7%) discontinued due to adverse events. CONCLUSIONS: Continuous use was associated with amenorrhea and fewer menstrual-related symptoms compared to cyclic use.
Rog?rio Bonassi Machado; Nilson Roberto de Melo; Hugo Maia
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-11-22
Journal Detail:
Title:  Contraception     Volume:  81     ISSN:  1879-0518     ISO Abbreviation:  Contraception     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-22     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
Department of Obstetrics and Gynecology, Jundia? School of Medicine, Jundia?, S?o Paulo, Brazil.
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MeSH Terms
Amenorrhea / chemically induced*
Analysis of Variance
Androstenes / administration & dosage*
Contraceptives, Oral, Combined / administration & dosage
Drug Administration Schedule
Ethinyl Estradiol / administration & dosage*
Intention to Treat Analysis
Longitudinal Studies
Metrorrhagia / chemically induced
Patient Satisfaction
Prospective Studies
Quality of Life
Statistics, Nonparametric
Treatment Outcome
Women's Health
Reg. No./Substance:
0/Androstenes; 0/Contraceptives, Oral, Combined; 57-63-6/Ethinyl Estradiol; 67392-87-4/drospirenone

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