Document Detail

Bleeding-induced decrease in duodenal HCO3- secretion in the rat is mediated via alpha 2-adrenoceptors.
MedLine Citation:
PMID:  3630720     Owner:  NLM     Status:  MEDLINE    
This study was performed on chloralosed rats in order to examine the influence of a minor blood loss on duodenal HCO3- secretion. The HCO3- output was measured by in situ titration in a duodenal segment. Blood loss of 0.6 ml per 100 g body wt (approximately 10% of total blood volume) reduced duodenal HCO3- secretion by about 30%. Pretreatment with guanethidine did not affect basal output of HCO3- but markedly reduced the bleeding-induced response. The alpha 2-adrenoceptor antagonist yohimbine did not affect the basal secretion but almost abolished the depression of duodenal HCO3- secretion due to blood loss. Pretreatment with the alpha 1-adrenoceptor antagonist prazosine or the beta-adrenoceptor antagonist propranolol did neither change basal duodenal HCO3- secretion nor the bleeding-induced decrease in duodenal HCO3- secretion. It is suggested that a small blood loss by means of a reflex activation of the sympathetic nervous system, and via the release of transmitter substances from adrenergic nerve endings, reduces the duodenal HCO3- secretion. The inhibitory effect is mainly due to activation of alpha 2-adrenoceptors.
C Jönson; L Fändriks
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  130     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-09-29     Completed Date:  1987-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  387-91     Citation Subset:  IM    
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MeSH Terms
Bicarbonates / secretion*
Duodenum / secretion*
Guanethidine / pharmacology
Hemorrhage / physiopathology*
Prazosin / pharmacology
Propranolol / pharmacology
Rats, Inbred Strains
Secretory Rate / drug effects
Sympatholytics / pharmacology*
Yohimbine / pharmacology
Reg. No./Substance:
0/Bicarbonates; 0/Sympatholytics; 146-48-5/Yohimbine; 19216-56-9/Prazosin; 525-66-6/Propranolol; 55-65-2/Guanethidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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