Document Detail

Bleeding in acute promyelocytic leukemia (APL): fibrinolysis or defibrination?
MedLine Citation:
PMID:  1945823     Owner:  NLM     Status:  MEDLINE    
The coagulation abnormalities in 20 cases of acute promyelocytic leukemia (APL) treated at a single institution were reviewed. A remarkably uniform picture of defibrination and increased FDPs with well-preserved levels of other coagulation factors including AT-III was seen. Our data, together with those available in the literature, do not support DIC as the underlying mechanism of bleeding but seem rather to point to increased proteolysis as the cause.
I Krsnik; A Escribá; M López-Rubio; C Alarcón; E del Potro; J Díaz-Mediavilla
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nouvelle revue française d'hématologie     Volume:  33     ISSN:  -     ISO Abbreviation:  Nouv Rev Fr Hematol     Publication Date:  1991  
Date Detail:
Created Date:  1991-12-06     Completed Date:  1991-12-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909092     Medline TA:  Nouv Rev Fr Hematol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  39-41     Citation Subset:  IM    
Servicio de Hematología, Hospital Clínico de San Carlos, Madrid, Espagne.
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MeSH Terms
Blood Coagulation Disorders / etiology*
Fibrin / metabolism*
Fibrinolysis / physiology*
Hemorrhage / etiology*
Leukemia, Promyelocytic, Acute / complications,  physiopathology*
Retrospective Studies
Reg. No./Substance:

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