Document Detail


Bleeding in acute promyelocytic leukemia (APL): fibrinolysis or defibrination?
MedLine Citation:
PMID:  1945823     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The coagulation abnormalities in 20 cases of acute promyelocytic leukemia (APL) treated at a single institution were reviewed. A remarkably uniform picture of defibrination and increased FDPs with well-preserved levels of other coagulation factors including AT-III was seen. Our data, together with those available in the literature, do not support DIC as the underlying mechanism of bleeding but seem rather to point to increased proteolysis as the cause.
Authors:
I Krsnik; A Escribá; M López-Rubio; C Alarcón; E del Potro; J Díaz-Mediavilla
Related Documents :
14663163 - Granulocytic sarcoma of the pancreas. a report of one case and review of the literature.
8562943 - Leukemia-associated changes identified by quantitative flow cytometry. iv. cd34 overexp...
579593 - Fetal death secondary to constriction and torsion of the umbilical cord.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nouvelle revue française d'hématologie     Volume:  33     ISSN:  -     ISO Abbreviation:  Nouv Rev Fr Hematol     Publication Date:  1991  
Date Detail:
Created Date:  1991-12-06     Completed Date:  1991-12-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909092     Medline TA:  Nouv Rev Fr Hematol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  39-41     Citation Subset:  IM    
Affiliation:
Servicio de Hematología, Hospital Clínico de San Carlos, Madrid, Espagne.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Coagulation Disorders / etiology*
Female
Fibrin / metabolism*
Fibrinolysis / physiology*
Hemorrhage / etiology*
Humans
Leukemia, Promyelocytic, Acute / complications,  physiopathology*
Male
Retrospective Studies
Chemical
Reg. No./Substance:
9001-31-4/Fibrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fast PCR-based quantitative detection of B-cell malignancies.
Next Document:  Acute megakaryocytic leukemia (AMKL) with major myelofibrosis in an infant. Diagnosis by liver biops...