Document Detail


Bleeding from self-administration of phenindione: a detailed case study.
MedLine Citation:
PMID:  1009028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A young woman presented with a 2 year history of a severe bleeding disorder and marked deficiencies in all four vitamin-K-dependent factors. Metabolic studies with tracer doses of tritium-labelled vitamin K1 suggested that the patient might be taking an oral anticoagulant; and subsequently her plasma was found to contain a substance identical to phenindione in its spectrophotometric and chromatographic properties. The half-disappearance times of factors II, IX, X were measured after the administration of a concentrate of these factors and were found to conform with published figures. The concentrate controlled the patient's excessive bruising and prolonged skin and gingival bleeding. It would therefore seem that factor VII may not be essential in reversal of the bleeding disorder induced by anticoagulant overdose.
Authors:
P A Gover; G I Ingram; M S Cork; L Holland; R P Hopkins; P Callaghan; P Barkhan; M J Shearer
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  33     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1976 Aug 
Date Detail:
Created Date:  1977-03-21     Completed Date:  1977-03-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  551-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia / complications
Blood Coagulation Disorders / drug therapy,  etiology*
Blood Coagulation Factors / therapeutic use
Blood Coagulation Tests
Chromatography, Gas
Chromatography, Thin Layer
Diabetes Complications
Female
Glucosephosphate Dehydrogenase / blood
Hematemesis / complications
Hematuria / complications
Humans
Menorrhagia / complications
Phenindione* / blood
Self Medication
Spectrum Analysis
Substance-Related Disorders*
Vitamin K / blood,  therapeutic use,  urine
Warfarin / blood
Chemical
Reg. No./Substance:
0/Blood Coagulation Factors; 12001-79-5/Vitamin K; 81-81-2/Warfarin; 83-12-5/Phenindione; EC 1.1.1.49/Glucosephosphate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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