Document Detail

Bleeding from the bone marrow enhances remodeling of the in situ frozen-thawed anterior cruciate ligament.
MedLine Citation:
PMID:  17601640     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this study is to biomechanically and histologically evaluate the effect of bleeding from bone marrow on remodeling of the in situ frozen-thawed anterior cruciate ligament. METHODS: Forty-four rabbits were used. Eight rabbits were used to evaluate the amount of bleeding at days 1-4. Thirty-six rabbits were divided into two groups, after the right anterior cruciate ligament underwent the freeze-thaw treatment. In Group I, no treatments were applied. In Group II, a tunnel was drilled into the bone marrow the femoral intercondylar notch. Each rabbit was sacrificed at 6 or 12 weeks. We examined the mechanical properties, and the histology of the anterior cruciate ligament. FINDINGS: A small amount of blood clot was observed only on the first day in Group I, while a large amount of blood clot was seen around the anterior cruciate ligament for 3 days after surgery in Group II. In the midsubstance, a number of cells were scattered in Group II, no cells were seen in Group I at 6 weeks. The tangent modulus showed some tendency of difference between Groups I and II at each period. INTERPRETATION: Bleeding from the bone marrow obviously enhanced extrinsic cell infiltration into the in situ frozen-thawed anterior cruciate ligament at 6 weeks, and showed some effects on its mechanical properties. This study implied that, in anterior cruciate ligament reconstruction, the blood from a bone tunnel play an important role in graft remodeling.
Kazunori Yasuda; Toshihiko Sakai; Eiji Kondo; Shin Onodera
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-29
Journal Detail:
Title:  Clinical biomechanics (Bristol, Avon)     Volume:  22     ISSN:  0268-0033     ISO Abbreviation:  Clin Biomech (Bristol, Avon)     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-22     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8611877     Medline TA:  Clin Biomech (Bristol, Avon)     Country:  England    
Other Details:
Languages:  eng     Pagination:  941-9     Citation Subset:  IM    
Department of Sports Medicine and Joint Reconstruction Surgery, Hokkaido University School of Medicine, Kita-15 Nishi-7, Kita-ku, Sapporo 060-8638, Japan.
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MeSH Terms
Anterior Cruciate Ligament / cytology*,  physiology*
Blood Coagulation / physiology*
Bone Marrow / physiology*
Bone Marrow Cells / physiology*
Cryopreservation / methods*

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