Document Detail


Bleeding of a familial cerebral cavernous malformation after prophylactic anticoagulation therapy. Case report.
MedLine Citation:
PMID:  16859253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The risk of hemorrhage in cavernous malformations (CMs) depends on lesion, host, and environmental factors. Anticoagulation therapy is a well-known risk factor for intracerebral bleeding, but the occurrence of hemorrhages in patients with CMs has not been reported. Low molecular weight heparin therapy is generally considered to be safe, although significant hemorrhagic complications have recently been reported. The authors report a case of intralesional bleeding in a CM after prophylactic anticoagulation therapy was administered in a patient with the familial form of the disease. The leaky endothelial structure of CMs may constitute an unexpected target of the vascular effects of heparin.
Authors:
Eugenio Pozzati; Mino Zucchelli; Anna Federica Marliani; Luca Albini Riccioli
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-07-15
Journal Detail:
Title:  Neurosurgical focus     Volume:  21     ISSN:  1092-0684     ISO Abbreviation:  Neurosurg Focus     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-24     Completed Date:  2006-08-18     Revised Date:  2008-05-06    
Medline Journal Info:
Nlm Unique ID:  100896471     Medline TA:  Neurosurg Focus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e15     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Bellaria Hospital, Bologna, Italy. Eugenio.Pozzati@ausl.bo.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticoagulants / adverse effects
Brain Neoplasms / complications*,  diagnosis,  physiopathology
Cerebral Cortex / blood supply,  pathology,  physiopathology
Cerebral Hemorrhage / chemically induced*,  physiopathology
Cerebral Veins / drug effects*,  pathology,  physiopathology
Endothelium, Vascular / drug effects,  physiopathology
Female
Genetic Predisposition to Disease / genetics
Hemangioma, Cavernous, Central Nervous System / complications*,  diagnosis,  physiopathology
Heparin, Low-Molecular-Weight / adverse effects*
Humans
Hysterectomy
Leiomyoma / surgery
Magnetic Resonance Imaging
Microtubule-Associated Proteins / genetics
Mutation / genetics
Postoperative Care
Proto-Oncogene Proteins / genetics
Risk Factors
Thrombosis / drug therapy,  prevention & control
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Heparin, Low-Molecular-Weight; 0/KRIT1 protein, human; 0/Microtubule-Associated Proteins; 0/Proto-Oncogene Proteins

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