| Bleeding of a familial cerebral cavernous malformation after prophylactic anticoagulation therapy. Case report. | |
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MedLine Citation:
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PMID: 16859253 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The risk of hemorrhage in cavernous malformations (CMs) depends on lesion, host, and environmental factors. Anticoagulation therapy is a well-known risk factor for intracerebral bleeding, but the occurrence of hemorrhages in patients with CMs has not been reported. Low molecular weight heparin therapy is generally considered to be safe, although significant hemorrhagic complications have recently been reported. The authors report a case of intralesional bleeding in a CM after prophylactic anticoagulation therapy was administered in a patient with the familial form of the disease. The leaky endothelial structure of CMs may constitute an unexpected target of the vascular effects of heparin. |
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Authors:
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Eugenio Pozzati; Mino Zucchelli; Anna Federica Marliani; Luca Albini Riccioli |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-07-15 |
Journal Detail:
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Title: Neurosurgical focus Volume: 21 ISSN: 1092-0684 ISO Abbreviation: Neurosurg Focus Publication Date: 2006 |
Date Detail:
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Created Date: 2006-07-24 Completed Date: 2006-08-18 Revised Date: 2008-05-06 |
Medline Journal Info:
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Nlm Unique ID: 100896471 Medline TA: Neurosurg Focus Country: United States |
Other Details:
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Languages: eng Pagination: e15 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Bellaria Hospital, Bologna, Italy. Eugenio.Pozzati@ausl.bo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticoagulants / adverse effects Brain Neoplasms / complications*, diagnosis, physiopathology Cerebral Cortex / blood supply, pathology, physiopathology Cerebral Hemorrhage / chemically induced*, physiopathology Cerebral Veins / drug effects*, pathology, physiopathology Endothelium, Vascular / drug effects, physiopathology Female Genetic Predisposition to Disease / genetics Hemangioma, Cavernous, Central Nervous System / complications*, diagnosis, physiopathology Heparin, Low-Molecular-Weight / adverse effects* Humans Hysterectomy Leiomyoma / surgery Magnetic Resonance Imaging Microtubule-Associated Proteins / genetics Mutation / genetics Postoperative Care Proto-Oncogene Proteins / genetics Risk Factors Thrombosis / drug therapy, prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Heparin, Low-Molecular-Weight; 0/KRIT1 protein, human; 0/Microtubule-Associated Proteins; 0/Proto-Oncogene Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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