Document Detail


Blebbing as a physical force in cancer EMT - Parallels with mitosis.
MedLine Citation:
PMID:  22659342     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Epithelial to mesenchymal transition (EMT) during metastasis is initially a two-step process beginning with delamination of cells from the solid tumor followed by acquisition of a migratory phenotype. Several reports indicate that plasma membrane blebbing, associated with cell division, coincides with cell delamination during developmental EMT. This raises a speculative question if blebbing drives EMT in cancer cells in a similar way. Here, we review available data on factors and processes that may support such a connection.
Authors:
Petra Sekyrova; Joel Ostblom; Michael Andäng
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-31
Journal Detail:
Title:  Seminars in cancer biology     Volume:  -     ISSN:  1096-3650     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-6-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010218     Medline TA:  Semin Cancer Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Affiliation:
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles vag 1, SE 171 77 Stockholm, Sweden.
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