| Bleb vascularity following post-trabeculectomy subconjunctival bevacizumab: a pilot study. | |
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MedLine Citation:
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PMID: 22429268 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: To determine whether postoperative subconjunctival bevacizumab significantly alters bleb vascularity. Design: A randomised, prospective interventional study. Participants: 43 eyes from 39 patients were recruited, with 21 eyes randomised to subconjunctival injections of 5-FU, and 22 eyes to combined 5-FU/bevacizumab. Methods: All patients who underwent uncomplicated primary anti-metabolite augmented trabeculectomy who subsequently required post-operative subconjunctival 5-Fluorouracil (5-FU) injection within 4 weeks of surgery were eligible. Patients were randomised to receive subconjunctival 5-FU only (7.5mg/0.15ml) or 5 FU plus bevacizumab (1.25mg/0.05ml). Main Outcome Measures: Primary outcome was bleb vascularity with secondary endpoints including visual acuity (VA), intraocular pressure (IOP), bleb morphology, complications and total numbers of 5-FU injections were recorded at baseline, week 12 and 18 months. Results: At week 12, there was no significant difference between groups for VA, IOP, bleb vascularity and morphology or total number of 5-FU injections. By 18 months, 47.4% of the 5-FU/bevacizumab group exhibited central bleb avascularity compared to 21.1% of the 5 FU group (Fisher exact test, p = 0.17). 2 bleb complications (1 blebitis; 1 suture abscess) recorded in the 5 FU/bevacizumab group. Conclusions: After a single combined injection a trend for increased central bleb avascularity was observed; although this effect was not sufficient to reach statistical significance. This in addition to the occurrence of two bleb related complications in the bevacizumab group suggest the need for a larger clinical trial to further evaluate the safety and efficacy of bevacizumab as a modulating agent in glaucoma filtration surgery. © 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists. |
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Authors:
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Brian E Chua; Dan Q Nguyen; Queena Qin; Jonathan B Ruddle; Anthony P Wells; Nuwan Niyadurupola; Viney Gupta; Tina T Wong; Michael A Coote; Jonathan G Crowston |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-19 |
Journal Detail:
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Title: Clinical & experimental ophthalmology Volume: - ISSN: 1442-9071 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100896531 Medline TA: Clin Experiment Ophthalmol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists. |
Affiliation:
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Centre for Eye Research Australia, Department of Ophthalmology, University of Melbourne, Australia and Royal Victorian Eye & Ear Hospital, Melbourne, Australia Ophthalmology Department, Wellington Hospital, Capital & Coast District Health Board, Wellington, New Zealand Dr. Rajendra Prasad Centre for Ophthalmic Sciences, India Singapore National Eye Centre, Singapore. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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