Document Detail

Blastomycotic cranial osteomyelitis.
MedLine Citation:
PMID:  1449188     Owner:  NLM     Status:  MEDLINE    
This is the second case report of a temporal bone osteomyelitis caused by Blastomyces dermatitidis, which presented as a chronic serous otitis media. The presenting serous otitis media was refractory to conventional medical and surgical management and progressed to a temporal bone osteomyelitis prior to diagnosis. B. dermatitidis is a rare fungal pathogen that causes a systemic pyogranulomatous disease that primarily manifests itself in the skin, bones, pulmonary, and genitourinary systems. If left untreated it is associated with a high rate of mortality. The otologic presentation of this rare disease is emphasized, while the clinical and therapeutic features are reviewed.
R C Farr; G Gardner; J D Acker; J M Brint; L F Haglund; M Land; J B Schweitzer; B C West
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of otology     Volume:  13     ISSN:  0192-9763     ISO Abbreviation:  Am J Otol     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-29     Completed Date:  1992-12-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7909513     Medline TA:  Am J Otol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  582-6     Citation Subset:  IM    
Department of Otolaryngology, University of Tennessee, Memphis 38103.
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MeSH Terms
Amphotericin B / administration & dosage,  pharmacology,  therapeutic use
Blastomyces / classification,  isolation & purification,  pathogenicity
Blastomycosis / complications,  diagnosis*,  drug therapy
Central Nervous System / drug effects
Ear, Middle / pathology,  physiopathology,  surgery
Granuloma / complications,  pathology,  surgery
Hearing Loss, Conductive / etiology,  physiopathology
Ketoconazole / administration & dosage,  therapeutic use
Magnetic Resonance Imaging
Osteomyelitis / complications,  diagnosis*
Otitis Media / diagnosis,  etiology
Temporal Bone
Grant Support
Reg. No./Substance:
1397-89-3/Amphotericin B; 65277-42-1/Ketoconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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